The sides are currently separated by just one point and one place in the league table, and the clash promises to be a keenly-contested one.
Match preview
Estudiantes failed to win away from home for the fifth game running following a 2-1 loss against Tigre at the Estadio Jose Dellagiovanna on Sunday.
Ricardo Zielinski's men were left with a mountain to climb having conceded goals in either half to Marco Retegui and Facundo Colidio before Pablo Piatti pulled one back midway through the second period.
Consequently, Los Pincharratas have now dropped down to 20th place in the Argentine Primera Division standings and are in need of a pick-me-up.
Coming up next is the challenge of an opposing outfit who are seeking revenge for a heavy 6-1 thrashing in the only previous meeting between the teams.
Having lost just two of their last 14 games on home turf, Wednesday's hosts are once again huge favourites to get the job done in front of an expectant crowd.
Barracas Central saw their run of three games undefeated in the league come to an end courtesy of a 3-1 defeat against Argentinos Jrs at the Claudio Fabian Tapia on Saturday.
After going behind to Fausto Vera's opener, Alfredo Berti's men drew level through Neri Bandiera shortly afterwards before second-half strikes from the aforementioned Vera and Jose Herrera decided the game.
With nine points amassed from a possible 24 this term, Los Camioneros sit 19th in the league table at the moment and will be looking to move up the standings in the coming weeks.
Unbeaten in six of their last seven games on the road, Wednesday's visitors have proven themselves to be no pushovers away from home.
Estudiantes Argentine Primera Division form:
Estudiantes form (all competitions):
Barracas Central Argentine Primera Division form:
Barracas Central form (all competitions):
Team News
Estudiantes La Plata's Ezequiel Munoz has not featured since March as the defender continues to battle with a damaged knee ligament.
Manuel Castro was on target in this most recent encounter between Wednesday's opponents, and the 26-year-old will be looking to deliver the goods once more.
After coming off the bench to good effect last time out, Pablo Piatti could be rewarded with a place in the starting lineup this time around.
Nicolas Ferreyra was hauled off for Barracas Central with a first-half injury against Argentinos Juniors, making him a doubt for this one.
The Argentine duo of Facundo Castro and Daniel Martinez are both unavailable for the away side due to ankle and thigh injuries respectively.
Estudiantes possible starting lineup:
Andujar; Mas, Lollo, Rodriguez, Mancuso; Zapiola, Morel, Zuqui, Castro; Diaz, Heredia
Barracas Central possible starting lineup:
Gagliardo; Blasi, Ferreyra, Paz, Diaz; Mater, Arce, Calderara; Tapia, Bandiera, Sepulveda