The Rams are sitting in second place in the League One table, while the Trotters are just one point adrift in third position.
Match preview
After finishing February with consecutive defeats, Derby have got their promotion bid back on track with three successive victories.
The Rams claimed 3-0 wins over Port Vale and Bristol Rovers, before they edged past Reading in Tuesday's home fixture.
After seeing Dwight Gayle's opener cancelled out by Sam Smith, Derby were given a boost when the Royals were reduced to 10 men in the 59th minute.
Conor Hourihane ultimately went on to score the winner, keeping his composure from the penalty spot to clinch Derby's third win in four home games.
Although they will face a tough test this weekend, the hosts can draw inspiration from the fact they have won each of their last five home games against Bolton, including a narrow 2-1 victory when the two sides last faced off at Pride Park in January 2023.
Bolton played out consecutive 2-2 draws in their away meetings with Barnsley and Exeter City, before they returned to winning ways with a dominant performance in Tuesday's home game against Oxford United.
Nathan Ogbeta, Josh Dacres-Cogley, George Thomason, Aaron Collins and Josh Sheehan all got on the scoresheet to guide the Trotters to a resounding 5-0 victory, extending their unbeaten run to four matches.
The Trotters will now turn their focus to Saturday's crucial encounter, where they will have to end a four-game winless away run if they are to leapfrog Derby into second place.
They have also failed to win any of their previous nine away games against the Rams since recording a 2-1 victory in a League Cup fixture in October 1999.
Nevertheless, they do have the chance to complete a league double over the Rams after claiming a 2-1 win in the reverse fixture thanks to goals from Dion Charles and Dacres-Cogley.
Derby County League One form:
W
L
L
W
W
W
Bolton Wanderers League One form:
L
L
W
D
D
W
Team News
Derby are having to cope with a lengthy injury list which includes Josh Vickers, Jake Rooney, Ryan Nyambe, Max Bird, Conor Washington and Tyreece-John Jules.
The Rams also remain without the services of their top scorer James Collins, who is recovering from a knee injury he sustained last month.
Midfielder Tyrese Fornah will have to be assessed ahead of the weekend after he missed the midweek win over Reading with a back problem.
As for the visitors, Victor Adeboyejo will be out for around four to six weeks after he picked up a hamstring injury against Exeter City earlier this month.
The forward is joined on the sidelines by Carlos Mendes, Dan Nlundulu, Nathan Baxter and Bolton's top scorer, Charles.
After seeing his side brush past Oxford, Bolton boss Ian Evatt could be tempted to select an unchanged starting lineup for Saturday's contest.
Derby County possible starting lineup:
Wildsmith; Cashin, Bradley, Nelson; Ward, Hourihane, Adams, Sibley; Barkhuizen; Mendez-Laing, Gayle
Bolton Wanderers possible starting lineup:
Coleman; Jones, Santos, Toal; Dacres-Cogley, Maghoma, Thomason, Ogbeta; Bodvarsson, Collins
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