While the Blues have picked up just one point from their opening two top-fight games, the Hatters have lost their one and only league fixture since securing promotion last season.
Match preview
After Chelsea rescued a respectable 1-1 draw against Liverpool and showed signs of promise in their opening Premier League game of the new season, Mauricio Pochettino was left with plenty to ponder when his side suffered a 3-1 away defeat to London rivals West Ham United last Sunday.
A sweet strike from Carney Chukwuemeka - his first goal for the Blues - cancelled out Nayef Aguerd's opener in the first half, but two of Chelsea's biggest outlays during the Todd Boehly era endured an afternoon to forget at the London Stadium.
Indeed, Enzo Fernandez - a £107m January arrival from Benfica - missed from the penalty spot on the stroke of half time before Michail Antonio put the Hammers in front, and then British-record £115m signing Moises Caicedo came on for his debut as a second-half substitute, shortly after Aguerd was sent off, only to give away a late penalty that Lucas Paqueta comfortably dispatched to condemn the Blues to their first defeat under Pochettino.
The Argentine boss believes it is only a matter of time before his young Chelsea side begin to click and put together a run of victories, and positive results will certainly be targeted in the coming weeks with Luton, Nottingham Forest and Bournemouth up next for the Blues in the top flight.
Chelsea, who last failed to win their opening three Premier League games back in 1998-99, cannot take Luton lightly on Friday, though, as the West Londoners dropped points in four of their six matches against newly-promoted teams last season.
Three months after winning the Championship playoff final, Luton put their mettle to the test in their first-ever Premier League match away at Brighton & Hove Albion on August 12, but the Hatters were second best against an effervescent Seagulls side who ran out 4-1 winners on the South Coast.
Solly March, Joao Pedro and Simon Adingra all made the net ripple for the hosts before Carlton Morris pulled one back for Luton from the penalty spot nine minutes from time, but Brighton restored their three-goal cushion through Evan Ferguson in the fifth minute of stoppage time.
Rob Edwards and co have since had a week off to recuperate and prepare for their challenging trip to Stamford Bridge, after their home encounter with Burnley was postposed as Kenilworth Road undergoes a significant makeover to comply with Premier League requirements.
Luton have made 10 signings so far this summer and although Edwards is happy with his current squad, mixed with fresh faces and a core group of stars that helped secure promotion, the Hatters boss is keen to recruit at least a couple more before the deadline.
The Bedfordshire-based outfit head into Friday's clash seeking to claim their first-ever Premier League points and their first victory over Chelsea since a 2-0 success in their most recent league meeting with the Blues back in December 1991 when they were last competing in the top flight. Chelsea have since won their last two encounters with Luton in the FA Cup, including a 3-2 away win in March 2022.
Chelsea Premier League form:
Luton Town Premier League form:
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Team News
Chelsea midfielder Chukwuemeka was forced off at half time with a knee injury in Sunday's defeat to West Ham and he is now facing up to six weeks on the sidelines after undergoing surgery.
Wesley Fofana, Christopher Nkunku (both knee), Reece James (hamstring) and Trevoh Chalobah (thigh) are also ruled out, and Mykhaylo Mudryk is doubtful after he missed training on Wednesday with an unspecified issue, but Benoit Badiashile and Armando Broja have returned to training following respective hamstring and knee problems and could feature in Friday's matchday squad.
The absence of Chukwuemeka could see Conor Gallagher pushed further forward and Moises Caicedo handed his full debut in centre-midfield alongside Enzo Fernandez; Romeo Lavia, meanwhile, will be hoping to making his first Blues appearance after joining from Southampton last week.
Raheem Sterling's performance was a notable positive for Pochettino in the defeat to West Ham, and the 28-year-old is expected to continue in attack alongside Nicolas Jackson, who is still searching for his first Chelsea goal in a competitive match.
As for Luton, Edwards revealed before the defeat at Brighton that Reece Burke (knock), Gabriel Osho (knee), Jordan Clark and Dan Potts (both ankle) are all ruled out for "a few weeks", and it seems unlikely that any of the quartet will feature on Friday.
Edwards is unlikely to make too many changes, if any, to the starting lineup that faced the Seagulls, with wing-backs Issa Kabore and Ryan Giles set to operate ahead of centre-back trio Mads Andersen, Tom Lockyer and Amari'i Bell.
Former Chelsea man Ross Barkley could be in contention to make his Luton debut, although Pelly Ruddock Mpanzu, Marvelous Nakamba and Tahith Chong are set to continue in centre-midfield, while Jacob Brown will push Elijah Adebayo for a start up front alongside Morris.
Chelsea possible starting lineup:
Sanchez; Disasi, Silva, Colwill; Gusto, Fernandez, Caicedo, Chilwell; Gallagher, Sterling; Jackson
Luton Town possible starting lineup:
Kaminski; Andersen, Lockyer, Bell; Kabore, Mpanzu, Nakamba, Chong, Giles; Adebayo, Morris
We say: Chelsea 2-0 Luton Town
Chelsea will be regarded as firm favourites to claim their first win under Pochettino on Friday, but Luton will hope to frustrate the hosts for as long as possible as they attempt to grind out a positive result.