Luxembourg will head into Tuesday's contest in a positive mood after picking up their first win of the qualifying campaign against Liechtenstein.
Match preview
After being named Bosnia-Herzegovina manager for the second time in his career in January, Faruk Hadzibegic got off to the perfect start, overseeing a commanding 3-0 home victory over Iceland.
As it proved, the honeymoon period lasted just one game, as Bosnia-Herzegovina rounded off the March international window with a disappointing 2-0 defeat to Slovakia.
They were unable to claim a positive result in Saturday's away trip to Portugal, falling to a heavy 3-0 defeat following a Bernardo Silva strike and Bruno Fernandes brace.
Bosnia-Herzegovina are now sitting in fourth position, with four points separating them from Slovakia, who occupy the second qualification place.
Having won their last five home internationals, Bosnia-Herzegovina will be looking forward to returning to home surroundings after suffering consecutive away defeats.
Luxembourg picked up one point from their opening two qualifying games in March, which produced a goalless draw against Slovakia and a heavy 6-0 defeat to Portugal.
In preparation for matchday three and four, Luc Holtz's side faced Malta in a friendly earlier this month, losing by a narrow 1-0 scoreline.
After going five internationals without a win, the Red Lions may have entered Saturday's home fixture with Liechtenstein in a downbeat mood.
However, they ended the contest with a positive outlook after recording a 2-0 victory thanks to goals from Danel Sinani and Gerson Rodrigues.
Luxembourg, who sit in third place in Group J, will now head on their travels, and they will be looking to claim their first away victory in European Championship qualifying since October 2007.
Bosnia-Herzegovina Euro Champ Qualifying form:
W
L
L
Bosnia-Herzegovina form (all competitions):
W
W
L
W
L
L
Luxembourg Euro Champ Qualifying form:
D
L
W
Luxembourg form (all competitions):
D
D
D
L
L
W
Team News
Adrian Leon Barisic made his Bosnia-Herzegovina debut on Saturday, and the 21-year-old is expected to retain his place in the back three alongside Sinisa Sanicanin and Anel Ahmedhodzic.
After featuring as a substitute against Portugal, Roma youngster Benjamin Tahirovic could be presented with a starting place.
Bosnia & Herzegovina's all-time leading scorer Edin Dzeko will be looking to add to the 64 goals he has scored for his country when he features in the forward line.
As for the visitors, Rodrigues is expected to be given a starting opportunity after coming off the bench to score against Liechtenstein.
Florian Bohnert also featured as a substitute in Saturday's contest, and he could slot in at right wing-back for Tuesday's encounter.
Sinani scored his 10th international goal at the weekend, and he will be looking to add to his tally when he features up front.
Bosnia-Herzegovina possible starting lineup:
Sehic; Ahmedhodzic, Sanicanin, Barisic; Dedic, Hadziahmetovic, Tahirovic, Kolasinac; Stevanovic, Dzeko
Luxembourg possible starting lineup:
Moris; Bohnert, Martins, Mahmutovic, Chanot, Jans; Borges Sanches, Martins Pereira, Barreiro, Rodrigues; Sinani