The home side set out to bounce back from a defeat last time out, while the visitors seek to record consecutive wins for the first time in five weeks.
Match preview
Boca Juniors suffered a disappointing 2-0 loss against Argentinos Juniors in Thursday's encounter at the Estadio Diego Armando Maradona.
Sebastian Battaglia's found themselves with a mountain to climb having conceded at the interval after conceding first-half goals to Gabriel Carabajal and Gaston Veron.
The Blue and Gold have slipped down to 15th place in the standings and are currently seven points off top spot after just nine rounds of matches.
Their next task comes against an opposing outfit with little to choose between the teams as the last 18 meetings have yielded eight wins apiece for either side and two draws.
Having snapped a three-game home losing streak in their last outing on home turf, Monday's hosts will be looking to pick up where they left off in front of their fans.
Estudiantes eased past the challenge of an out-of-sorts Barracas Central side in a 3-1 triumph at the Estadio Jorge Luis Hirschi in La Plata.
Ricardo Zielinski's men broke the deadlock early on through Leandro Diaz but they were pegged back by Ivan Tapia before second-half goals from Benjamin Rollheiser and Pablo Piatti put the game to bed after the restart.
Consequently, Los Pincharratas have risen to 17th place in the league table and now sit just three points shy of a place in the top 10.
Winless in their five matches away from home, Monday's visitors have significant work to do on their travels if they are to compete with the teams in the higher echelons of the standings this year.
Boca Juniors Argentine Primera Division form:
Boca Juniors form (all competitions):
Estudiantes Argentine Primera Division form:
Estudiantes form (all competitions):
Team News
Estudiantes' Ezequiel Munoz remains without an appearance since March as the defender continues to battle with a long-term knee injury.
Pablo Piatti head into Monday's contest looking to score for the third game in a row and the 33-year-old is definitely one to look out for.
Boca Juniors' Gabriel Aranda is set to sit out a fifth consecutive match with an ankle problem, while Carlos Izquierdoz misses out through a torn muscle.
The away side will also have to make do with the absence of Diego Gonzalez who continue his spell on the treatment table due to a knee injury.
Boca Juniors possible starting lineup:
Rossi; Fabra, Rojo, Zambrano, Advincula; Cano, Campuzano, Fernandez, Zeballos; Vazquez, Orsini
Estudiantes possible starting lineup:
Andujar; Godoy, Morel, Lollo, Mas; Rodriguez, Zuqui; Castro, Piatti, Rollheiser; Diaz