The visitors are mathematically unable to finish in the top two, but they still have a chance to fight for a place in the Copa Subamericana in this match.
Match preview
Atletico Nacional have impressed so far in the Copa Libertadores, having only lost one of their five group games heading into Wednesday.
This has left the team in second place, and while they have guaranteed a place in the next round due to the gap between them and the bottom two teams, they can still fight to win the group.
Right now Atletico Nacional sit just a point behind Olimpia which means there is everything to play for in the final games of the group stage.
Paulo Autuori's men are undefeated in their past four games in all competitions heading into this match, providing plenty of confidence to the squad.
They will also take belief from the fact that they defeated Patronato 2-1 the last time they competed in this competition with a brace from Dorlan Pabon being the decider.
The visitors might not be competing for a place in the top of the group, but they do still have plenty to play for when it comes to this match.
While they are currently bottom of the group, Patronato could push them into third place which would allow them to compete in the Copa Subamericana.
Right now there is just a single point between them and Melgar, meaning even a victory does not guarantee them the chance to progress, especially since goal difference is not on their side either.
Patronato have conceded 11 goals in their five matches so far, which is an area for improvement heading into this match and beyond.
So far they have only won a single match in the competition and they head into this on the back of a 2-1 loss in their latest league match as well.
Atletico Nacional Copa Libertadores form:
W
W
D
W
L
Patronato Copa Libertadores form:
L
L
W
L
L
Patronato form (all competitions):
W
L
L
W
L
L
Team News
Pabon is the main attacking threat for the hosts in this match, and he is likely going to be a key part of the attack from the first whistle.
Jefferson Duque is another option for Atletico Nacional as they could end up featuring him alongside Pablon, which proved to be successful at the weekend.
Cristian Gonzalez will be tested at the heart of the Patronato defence, especially since leaking goals has been a problem for the team this season.
The visitors have typically been operating a back three, but against stern opposition that is something that could end up being tweaked.
Atletico Nacional possible starting lineup:
Mier; Banguero, Zapata, Aguirre, Candelo; Gomez, Palacio, Deossa; Perea, Pabon, Palacios
Patronato possible starting lineup:
Salva; Ruiz Diaz, Ojeda, Gonzalez, Cobos; Domingo, Chamorro; Solis, Barinaga, Esquivel; Levato
We say: Atletico Nacional 2-0 Patronato
Patronato have struggled in this competition so far, and that is something that is likely to continue in the final match due to the strength of the Atletico Nacional squad.