The Belgian visitors ran out 1-0 winners in front of their own supporters last week, despite seeing out the final 40 minutes of that encounter with 10 men.
Match preview
Possibly still nursing a European hangover from their astonishing third-round success over Dinamo Zagreb - where Croatian defensive stalwart Domagoj Vida came up with the crucial contribution against his old club - AEK Athens could not find a way past the 10 men of Antwerp last week.
Former Tottenham Hotspur striker Vincent Janssen drew first blood for the Belgian outfit with 16 minutes on the clock, and despite losing left-back Jelle Bataille to a straight red card just six minutes into the second half, Antwerp successfully shut up shop.
Despite huffing and puffing for almost the entirety of the second half, AEK Athens - who had 64% of the ball and fired 23 attempts on goal - clearly forgot to bring their shooting boots with them to Belgium, as only four of their shots found the target, and it was a similar story in the weekend's Greek Super League opener.
Indeed, the reigning champions were held to a 1-1 draw by Panserraikos, who opened the scoring in the first minute through Kosta Aleksic before Mijat Gacinovic levelled deep into the second half for Matias Almeyda's men, who demonstrated another total lack of ruthlessness on the day.
This time around, the Double-Headed Eagle ended the game with a staggering 82% possession, but only eight of their 36 shots tested opposing goalkeeper Adrian Chovan, and such profligacy could prove very costly indeed on the biggest continental stage.
Bataille's 51st-minute sending-off was not in the script for Royal Antwerp during their third Champions League match, but the team led by Mark van Bommel - a former European Cup winner with Barcelona - are now just 90 minutes away from making history.
Prior to the 2023-24 preliminary rounds, Antwerp had only ever competed in two top-level continental matches - suffering an 8-1 aggregate obliteration at the hands of Real Madrid in the 1957-58 European Cup - and since then, a handful of Europa League group-stage showings is all that the Reds have had to shout about.
However, Van Bommel's team were granted a weekend off from Jupiler Pro League action as they gear up for a daunting trip to Athens, but while the Great Old have become renowned for staunch defensive displays on their own patch, it has been a different story on the road.
Indeed, Antwerp have failed to win any of their last four competitive fixtures away from home - losing twice and drawing twice in that underwhelming sequence - prior to which they had strung together a five-game winning streak on rival turf with five clean sheets in tow.
Wednesday's crunch clash will mark just Antwerp's second competitive fixture on Greek soil, having suffered a 2-1 loss to Olympiacos in the 2021-22 Europa League group stage, during which Bataille fell foul of the rulebook once again as he was sent off late on.
AEK Athens Champions League form:
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AEK Athens form (all competitions):
Royal Antwerp Champions League form:
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Royal Antwerp form (all competitions):
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Team News
AEK Athens' goalscoring woes have not been helped by a recent injury to striker Levi Garcia, who lasted just 36 minutes in last week's first-leg loss to Antwerp before having to be replaced due to a thigh injury.
The issue is expected keep the Trinidad and Tobago attacker out for a couple of weeks, meaning that he will not be at the hosts' disposal for the second leg, and nor will winger Paolo Fernandes, whose Achilles issue will take months to heal.
Tom van Weert should be given the nod in the number nine spot as Garcia recovers, while Gacinovic equalised for the Greek champions just seven minutes after coming off the bench at the weekend and ought to force his way back into the XI too.
As mentioned, Antwerp left-back Bataille will not have a shot at redemption in Greece following his straight red card in the first leg, and the 24-year-old's absence only complicates Van Bommel's defensive dilemma further.
The visiting manager is already coping without one full-back in Kobe Corbaine, while centre-back Bjorn Engels is dealing with an Achilles problem, and goalkeeping duo Davino Verhulst (eye) and Ortwin de Wolf (finger) are missing too.
American defender Sam Vines should be promoted from the bench in place of the banned Bataille, but Van Bommel should otherwise see no reason to alter a winning formula, as Toby Alderweireld partners a man 15 years his junior in Soumaila Coulibaly in the heart of the rearguard.
AEK Athens possible starting lineup:
Athanasiadis; Sidibe, Vida, Moukoudi, Mohammadi; Jonsson, Pineda; Amrabat, Mantalos, Gacinovic; Van Weert
Royal Antwerp possible starting lineup:
Butez; De Laet, Alderweireld, Coulibaly, Vines; Keita, Vermeeren; Ondrejka, Ekkelenkamp, Balikwisha; Janssen
We say: AEK Athens 1-1 Royal Antwerp (Antwerp win 2-1 on aggregate)
Converting chances into goals has not been AEK Athens' forte over the past week, and the injury to Garcia will do the wasteful hosts no favours on the offensive front either.