The visitors, meanwhile, are seeking to claim successive top-flight victories for just the second time this season after picking up maximum points against Lecce last time out.
Match preview
Following a four-game winless run in all competitions, including away league defeats at Fiorentina and Udinese, AC Milan bounced back in emphatic fashion with a surprising, yet impressive, 4-0 victory away against Napoli on Sunday.
In-demand forward Rafael Leao starred for the Rossoneri and scored either side of half time, while Brahim Diaz and Alexis Saelemaekers were also on the scoresheet to help Stefano Pioli's men secure a statement Serie A win shortly before the two teams renew acquaintances in the Champions League quarter-finals next week.
Hopes of Milan retaining their top-flight title were quashed some time ago, with 20 points currently separating them from Napoli at the summit, and securing a place in next season's Champions League is now the sole focus for Pioli's side, who sit third in the table and only one point above Roma in fifth.
Three favourable-looking league fixtures against Empoli, Bologna and Lecce are up next for Milan in and around their Champions League tie with Napoli, and Pioli will be targeting maximum points from this run before ending the month with an important clash away against Roma.
The Rossoneri will be confident of success on Friday as they have won each of their last four Serie A meetings against Empoli, including a 3-1 away win in October; not since the days of former boss Carlo Ancelotti between 2003 and 2006 have Milan won five successive league matches against the Azzurri.
Empoli ended a miserable nine-game winless league run, including four straight defeats, when they secured a slender 1-0 home victory over Lecce on Monday night.
A converted penalty kick from January loan signing Francesco Caputo just after the hour mark proved to be the winning goal for the hosts, who managed to prevent their opponents from striking a single shot on target.
Paolo Zanetti's side will be confident of cementing their top-flight status for next season as they currently sit 14th in the Serie A standings and 12 points clear of the relegation zone, while the prospect of securing a top-10 finish cannot be ruled out as they are only seven points behind Torino in 10th with 10 games remaining.
Empoli head into Friday's contest having only won three of their 29 Serie A encounters against AC Milan, although all three victories have taken place at San Siro, while they have already beaten Inter Milan in the same stadium this year, winning 1-0 at the end of January.
AC Milan Serie A form:
W
W
L
D
L
W
AC Milan form (all competitions):
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L
D
D
L
W
Empoli Serie A form:
D
L
L
L
L
W
Team News
Milan trio Zlatan Ibrahimovic, Junior Messias (both thigh) and Pierre Kalulu (calf) all missed the win over Napoli due to injury and they will all be assessed ahead of kickoff on Friday.
Pioli may consider making a few changes, with one eye on next week's Champions League tie, but a back four of Davide Calabria, Simon Kjaer, Fikayo Tomori and Theo Hernandez is likely to remain intact, protecting goalkeeper Mike Maignan.
Former Empoli man Rade Krunic could keep his spot in centre-midfield alongside Ismael Bennacer and Sandro Tonali, while Leao - who has not scored at San Siro since November - is expected to continue on the left flank, joining Diaz and Olivier Giroud in attack.
As for Empoli, defender Lorenzo Tonelli is suspended after being sent off from the substitutes' bench for dissent against Lecce.
However, first-choice goalkeeper Guglielmo Vicario is expected to return to the starting lineup following a spell on the sidelines with concussion.
Caputo - who has scored 18 Serie A goals across two spells with Empoli - is set to continue in attack and will draw level with Ighli Vannucchi (19) as the club's fourth-highest scorer in the Italian top flight if he finds the net on Friday.
AC Milan possible starting lineup:
Maignan; Calabria, Kjaer, Tomori, Hernandez; Tonali, Bennacer, Krunic; Diaz, Giroud, Leao
Empoli possible starting lineup:
Vicario; Ebuehi, Ismajli, Luperto, Parisi; Bandinelli, Marin, Akpa Akpro; Baldanzi; Piccoli, Caputo
We say: AC Milan 2-0 Empoli
Both teams will be keen to build on their respective victories last time out, although AC Milan will be regarded as the favourites to come out on top in Friday's contest.
Empoli have already picked up three points at San Siro against Inter this term, but the Rossoneri should have few problems securing a routine win in front of their home supporters here.