Mikel Arteta's side demolished Bolton Wanderers 5-1 in round three, while their hosts won an epic 31-penalty shootout against Fulham, and here Sports Mole rounds up the team news for both clubs.
PRESTON NORTH END vs. ARSENAL
PRESTON NORTH END
Out: Milutin Osmajic (suspended), Robbie Brady (ankle), Ched Evans (discomfort), Patrick Bauer (elbow), Will Keane (tendon)
Doubtful: Josh Bowler (illness)
Sports Mole's predicted XI: Woodman; Kesler-Hayden, Hughes, Lindsay, Storey, Potts; Whiteman, Frokjaer-Jensen, Ledson; Greenwood, Riis
ARSENAL
Out: Neto (ineligible), Riccardo Calafiori (knee), Martin Odegaard (ankle), Takehiro Tomiyasu (knee), Kieran Tierney (hamstring)
Doubtful: Gabriel Magalhaes (knee), Jurrien Timber (cramp)
Sports Mole's predicted XI: Setford; Nichols, Saliba, Kiwior, Lewis-Skelly; Nwaneri, Jorginho, Rice; Sterling, Jesus, Martinelli
For data analysis of the most likely results, scorelines and more for this match please click here.