That mouth-watering showdown kicks off just before Man City are in action themselves away to Nottingham Forest, with the champions bringing the curtain down on the gameweek.
Out-of-form Liverpool kick things off at West Ham United on Saturday lunchtime as they look to keep their fast-fading title hopes alive in the hope of slip-ups from their rivals the following day.
Saturday could also see the first Premier League relegation of the season confirmed, with Sheffield United's fate potentially being sealed when they visit Newcastle United.
Each gameweek, Sports Mole is taking on a famous musician or band in a prediction competition, and this week it is the turn of Martin Moscrop of A Certain Ratio.
West Ham vs. Liverpool
Saturday, 12.30pm
Martin: West Ham 1-1 Liverpool
Sports Mole: West Ham 1-2 Liverpool
Man Utd vs. Burnley
Saturday, 3pm
Martin: Man Utd 3-1 Burnley
Sports Mole: Man Utd 2-1 Burnley
Fulham vs. Crystal Palace
Saturday, 3pm
Martin: Fulham 1-2 Crystal Palace
Sports Mole: Fulham 1-2 Crystal Palace
Newcastle vs. Sheff Utd
Saturday, 3pm
Martin: Newcastle 2-0 Sheff Utd
Sports Mole: Newcastle 4-0 Sheff Utd
Wolves vs. Luton
Saturday, 3pm
Martin: Wolves 0-0 Luton
Sports Mole: Wolves 2-1 Luton
Everton vs. Brentford
Saturday, 5.30pm
Martin: Everton 0-2 Brentford
Sports Mole: Everton 2-1 Brentford
Aston Villa vs. Chelsea
Saturday, 8pm
Martin: Aston Villa 2-1 Chelsea
Sports Mole: Aston Villa 2-2 Chelsea
Spurs vs. Arsenal
Sunday, 2pm
Martin: Spurs 1-0 Arsenal
Sports Mole: TBC - please check back later
Bournemouth vs. Brighton
Sunday, 2pm
Martin: Bournemouth 1-1 Brighton
Sports Mole: Bournemouth 2-1 Brighton
Nott'm Forest vs. Man City
Sunday, 4.30pm
Martin: Nott'm Forest 1-4 Man City
Sports Mole: Nott'm Forest 1-4 Man City
Martin Moscrop Q&A
How did you come to support Manchester United and what are your favourite memories from your time as a fan?
My Dad was a football supporter who used to go and see all the teams in the North-West including Man United, Man City, Preston North End, Burnley... and he would take me with him to some of them. Visiting Old Trafford and seeing Man Utd win for my first game there turned me instantly into a Red.
Who have been your favourite five players for your club?
George Best, Ryan Giggs, Eric Cantona, Paul Scholes and Denis Irwin.
What's going on with the band at the moment?
We have a new album out called 'It All Comes Down to This' and we start the tour in Huddersfield on April 25. We'll be visiting Leeds, Blackpool, Edinburgh, Aberdeen, Norwich, London, Bedford, Portsmouth, Brighton, Birmingham, Hull, Sheffield and Bristol and finish on May 17 at Manchester's New Century Hall.
Check out 'All Comes Down To This', the latest release from Manchester post-punk band A Certain Ratio, available on all digital streaming platforms now.
You can follow A Certain Ratio on Instagram and X (formerly known as Twitter).
2023-24 SEASON LEADERBOARD (ARTISTS)
Scores are calculated as one point for a correct result and five points for a correct scoreline.
1. SPRINTS' Sam (19pts | Gameweek 9)
2. Flat Party's Nic (18pts | Gameweek 7)
3. SPRINTS' Jack (16pts | Gameweek 9)
= Joshua Grant (16pts | Gameweek 30)
5. SPRINTS' Karla (14pts | Gameweek 9)
= Noah and the Loners' Noah Riley (14pts | Gameweek 20)
7. Palace's Leo Wyndham (13pts | Gameweek 24)
= Nathan Evans (13pts | Gameweek 28)
9. Flat Party's Dylan (12pts | Gameweek 7)
10. Swim Deep's Cavan McCarthy (11pts | Gameweek 33)
11. Flat Party's Rory (10pts | Gameweek 7)
= Master Peace (10pts | Gameweek 23)
13. Tom Speight (9pts | Gameweek 2)
= Majestic & Beyond Chicago (9pts | Gameweek 3)
= Sea Girls' Andrew Dawson (9pts | Gameweek 8)
16. New Rules' Ryan Meaney (8pts | Gameweek 6)
= K.A.D (8pts | Gameweek 12)
= Solar Eyes (8pts | Gameweek 25)
19. Kid Kapichi's Jack Wilson (7pts | Gameweek 5)
= Feeder's Taka Hirose (7pts | Gameweek 18)
= Fat White Family's Lias Saoudi (7pts | Gameweek 21)
= One True Pairing (7pts | Gameweek 29)
= Spinn's Louis O'Reilly (7pts | Gameweek 34) *
24. Ed Cosens (6pts | Gameweek 22)
= Only The Poets (6pts | Gameweek 27)
26. Sainte (5pts | Gameweek 13)
27. Insincere (4pts | Gameweek 1)
= STONE (4pts | Gameweek 10)
= Slick Don (4pts | Gameweek 14)
= The Blinders' Charlie McGough (4pts | Gameweek 15)
= Alex Spencer (4pts | Gameweek 16)
= Chiedu Oraka (4pts | Gameweek 26) *
= Corella's Joel Smith (4pts | Gameweek 32)
34. Barry Can't Swim (3pts | Gameweek 4)
= Keen Roy (3pts | Gameweek 11)
= The Mysterines' Paul Crilly (3pts | Gameweek 31)
= Public Order's Elis Lloyd Jones (3pts | Gameweek 29) *
38. Bill Ryder-Jones (2pts | Gameweek 19)
* = Gameweek with reduced number of fixtures
2023-24 COMPETITION HISTORY
Gameweek 1: Insincere 4-16 Sports Mole
Gameweek 2: Tom Speight 9-16 Sports Mole
Gameweek 3: Majestic & Beyond Chicago 9-9 Sports Mole
Gameweek 4: Barry Can't Swim 3-9 Sports Mole
Gameweek 5: Kid Kapichi's Jack Wilson 7-11 Sports Mole
Gameweek 6: New Rules' Ryan Meaney 8-10 Sports Mole
Gameweek 7: Flat Party's Rory, Nic & Dylan 10/18/12-3 Sports Mole
Gameweek 8: Sea Girls' Andrew Dawson 9-9 Sports Mole
Gameweek 9: SPRINTS' Jack, Same & Karla 16/19/14-16 Sports Mole
Gameweek 10: STONE 4-6 Sports Mole
Gameweek 11: Keen Roy 3-9 Sports Mole
Gameweek 12: K.A.D 8-8 Sports Mole
Gameweek 13: Sainte 5-2 Sports Mole
Gameweek 14: Slick Don 4-6 Sports Mole
Gameweek 15: The Blinders' Charlie McGough 4-4 Sports Mole
Gameweek 16: Alex Spencer 4-3 Sports Mole
Gameweek 17: N/A
Gameweek 18: Feeder's Taka Hirose 7-9 Sports Mole
Gameweek 19: Bill Ryder-Jones 2-7 Sports Mole
Gameweek 20: Noah and the Loners' Noah Riley 14-5 Sports Mole
Gameweek 21: Fat White Family's Lias Saoudi 7-10 Sports Mole
Gameweek 22: Ed Cosens 6-4 Sports Mole
Gameweek 23: Master Peace 10-12 Sports Mole
Gameweek 24: Palace's Leo Wyndham 13-11 Sports Mole
Gameweek 25: Solar Eyes 8-9 Sports Mole
Gameweek 26: Chiedu Oraka 4-5 Sports Mole *
Gameweek 27: Only The Poets 6-8 Sports Mole
Gameweek 28: Nathan Evans 13-2 Sports Mole
Gameweek 29: One True Pairing 7-3 Sports Mole *
Gameweek 30: Joshua Grant 16-10 Sports Mole
Gameweek 31: The Mysterines' Paul Crilly 3-9 Sports Mole
Gameweek 32: Corella's Joel Smith 4-7 Sports Mole
Gameweek 33: Swim Deep's Cavan McCarthy 11-14 Sports Mole
Gameweek 34: Spinn's Louis O'Reilly 7-5 Sports Mole *
Midweek fixtures: Public Order's Elis Lloyd-Jones 3-3 Sports Mole *
* = Gameweek with reduced number of fixtures
Barcelona 
Osasuna 
Krylya Sovetov 
Lokomotiv Moscow 
Aubagne 
Bordeaux 
Bayer Leverkusen 
VFL Bochum 
Strasbourg 
Lyon 
Gil Vicente 
Benfica 
Obolon-Brovar Kyiv 
Shakhtar Donetsk 
Sampdoria 
Frosinone 
Bayern Munich 
FC ST. Pauli 
Holstein Kiel 
Werder Bremen 
VFL Wolfsburg 
FC Heidenheim 
Celtic 
Heart Of Midlothian 
Espanyol 
Atletico Madrid 
Reims 
Marseille 
Rukh Lviv 
Dynamo Kyiv 
CSKA Moscow 
FK Makhachkala 
Juventus 
Genoa 
Eintracht Frankfurt 
VFB Stuttgart 
Dundee 
Rangers 
ST Etienne 
Paris Saint Germain 
Metz 
Lecce 
Roma 
Real Madrid 
Leganes 
NEC Nijmegen 
AZ Alkmaar 
Monaco 
Nice 
PSV 
Ajax 
Fiorentina 
Atalanta 
Akhmat Grozny 
Spartak Moscow 
Girona 
Feyenoord 
GO Ahead Eagles