With FA Cup fixtures occupying the schedule over the weekend, normal service resumes as clubs look ahead to a crucial few weeks in the top-flight.
As always, there are some big, big fixtures in store as well.
Tuesday night will see three games taking place with Newcastle hosting Everton, West Ham taking on Watford and Manchester United travelling to Turf Moor to face Burnley.
On Wednesday we have four matches to look forward to, with Manchester City v Brentford, Norwich v Crystal Palace, Tottenham v Southampton and Aston Villa v Leeds.
We then have another two encounters on Thursday night as Liverpool host Leicester at Anfield while Mikel Arteta's Arsenal travel to take on Wolves.
The only two teams who aren't in action are Chelsea and Brighton, with Thomas Tuchel's side away at the FIFA Club World Cup.
Premier League fixtures this week
Tuesday, February 8
Newcastle v Everton, 7.45pm
West Ham v Watford, 7.45pm
Burnley v Manchester United, 8pm
Eddie Howe will be hoping to hand out several debuts as Newcastle take on Everton on Tuesday night, with Dan Burn, Matt Targett and Bruno Guimaraes in contention to feature against Frank Lampard's side.
West Ham will host Watford at the London Stadium, while Ralf Rangnick's Manchester United will be hoping to bounce back from their FA Cup disappointment against Middlesbrough as they travel to take on Burnley.
Wednesday, February 9
Manchester City v Brentford, 7.45pm
Norwich v Crystal Palace, 7.45pm
Tottenham v Southampton, 7.45pm
Aston Villa v Leeds, 8pm
It's a busy Wednesday night with some big fixtures taking place at both ends of the table.
Man City will be hoping to extend their lead at the top of the Premier League as they host Brentford, while Tottenham will want to strengthen their top-four hopes against Southampton.
Norwich will be eager to get more points on the board against Crystal Palace, while Steven Gerrard's Aston Villa face Leeds in what could be an entertaining clash at Villa Park.
Thursday, February 10
Liverpool v Leicester, 7.45pm
Wolves v Arsenal, 7.45pm
On Thursday there are two big matches as Liverpool welcome former manager Brendan Rodgers and Leicester to Anfield.
Following the Foxes' defeat to Nottingham Forest in the FA Cup, they'll be hoping for a big performance against Jurgen Klopp's side.
Elsewhere, Arsenal face a tough test as they travel to Molineux to take on Bruno Lage's Wolves.
Premier League table
Premier League: How to follow
talkSPORT's Adrian Durham will be hosting Kick Off 'Around The Grounds' on both Tuesday and Wednesday evening.
This will include all of the goals as they go in with Micky Gray, Danny Mills and Aaron McLean on Tuesday night and Gray, Sam Parkin and Courtney Sweetman-Kirk reporting on Wednesday.
Coverage will start at 6pm on talkSPORT 2, before switching over to talkSPORT at 7pm and running until 10pm.
Will also have updates from both games on Thursday night on talkSPORT.
To tune in to talkSPORT or talkSPORT 2, click HERE for the live stream.
App iPhone - Download from the Apple store
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Radio - talkSPORT is available across the United Kingdom via DAB digital radio and on 1089 or 1053 AM
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All nine fixtures will also be live on BT Sport with their coverage starting on BT Sport 1 at 7pm each night.