The Reds have won two Premier League games in a row to close the gap on Tottenham in fourth to seven points with two games in hand.
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But Jurgen Klopp's men were brought back down to earth with a shuddering thud in midweek as they were thrashed 5-2 by Real Madrid in the Champions League.
Liverpool must quickly move on from that, but the Eagles are in desperate need of points themselves, having failed to win a league game in 2023.
They came very close to ending that run last weekend against Brentford, but the Bees grabbed a last-gasp equaliser to leave Patrick Vieira and co frustrated.
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So the nerves will be high in both dressing rooms as both teams seek what could be a huge victory.
Crystal Palace Liverpool: talkSPORT coverage
This Premier League clash is set to take place on Saturday, February 25.
Kick-off at Selhurst Park is scheduled for 7:45pm.
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talkSPORT will have live coverage from south London, with Faye Carruthers serving as your host.
Commentary will then come from Alex Crook and former Chelsea defender Scott Minto.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Crystal Palace v Liverpool: Team news
The hosts will once again be without Wilfried Zaha, with the mercurial forward set for a couple more weeks on the sidelines after suffering a hamstring injury.
But James McArthur is close to making his first appearance of the season.
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Apart from that, the Eagles have a fully fit squad to choose from.
Meanwhile, the Reds remain without Luis Diaz, Ibrahima Konate and Arthur Melo.
Joe Gomez was also withdrawn against Real Madrid with an injury, while Calvin Ramsay is out for the season.
But Diogo Jota and Roberto Firmino are fully fit and might come into the starting XI.
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Crystal Palace v Liverpool: What has been said?
Former Liverpool star Dietmar Hamann talking to talkSPORT about the Reds' problems: "If you look at the midfield and all the players they've got in that position, who are you going to keep for next season or who would you like to keep?
"Because obviously the ones who have got a contract, I'm not sure somebody will take them. If you look at the midfield now, you've got [Stefan] Bajcetic who's done well, he's a youngster of course you've got to keep him.
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"Harvey Elliott, Curtis Jones, they haven't progressed. Thiago I've never been a fan of, I don't think Liverpool is good enough to have a Thiago in the team at the moment.
"Fabinho hasn't been the same, [James] Milner is coming to the end, he's been a brilliant player. Then you've got [Naby] Keita and [Alex] Oxlade-Chamberlain who have been very disappointing since they've come.
"So, you probably need three of four midfielders alone and that takes a lot of money."
Crystal Palace v Liverpool: Match facts
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Following their 1-1 draw at Anfield in the reverse fixture, Crystal Palace are looking to avoid defeat in both Premier League meetings with Liverpool for the first time since 2014-15.
Liverpool have won their last seven Premier League away games against Crystal Palace by an aggregate score of 22-6. Only at Norwich (8 between 1995 and 2021) have the Reds had a longer away winning run in the competition.
Liverpool have lost two of their last three away Premier League games against London sides, as many as they had in their previous 24 visits to the capital (W14 D8). They lost 3-1 at Brentford in their last such match, last losing consecutive visits in April 2015.
Thanks to Brentford's late equaliser last time out, Crystal Palace remain winless in their last seven Premier League games (D4 L3). They last had a longer run without a victory in June/July 2020 (8 games).
After a run of four Premier League games without a win (D1 L3), Liverpool have won their last two. They've won them both by a 2-0 scoreline, having kept just one clean sheet in their previous 10 matches.
Liverpool are the only side yet to concede a goal from outside the box in the Premier League this season; last season, the Reds conceded a league-high share 27 per cent of their goals from distance (7/26).
Liverpool have had more shots from fast breaks (counter attacks) than any other Premier League side this season (19). However, the Reds have also faced more shots from fast breaks than anyone else (21), with only Everton (8) conceding more such goals (5).
No side has won more Premier League games when conceding the first goal than Crystal Palace this season (4). However, Liverpool are the only side with a 100 per cent win rate when scoring first in the competition this term (won 8/8).
Liverpool duo Mohamed Salah and Darwin Nunez create a chance for one another on average every 55 minutes in the Premier League this season, the best rate of any pair to have played at least 500 minutes together.
Cody Gakpo has scored in his last two Premier League appearances, with both of his strikes making the score 2-0 to Liverpool. No player has scored in three consecutive games for the Reds so far this season.