Manchester City are favourites to go all the way to Wembley after reaching the quarter-finals with a 3-1 win over Plymouth.
Aston Villa have also reached the last eight for the first time since 2015, while Crystal Palace have made it through too.
Manchester United, Newcastle, and Nottingham Forest will now also look to get a step closer to glory.
Keep up to date with all of the latest Premier League odds at talkSPORT BET
6 minutes agoBy Jack Cunningham
Good news
Crystal Palace have provided a positive update on Jean-Philippe Mateta after he was involved in a horrible incident on Saturday.
During the Eagles' FA Cup clash against Millwall, the striker was on the receiving end of a ridiculous challenge by goalkeeper Liam Roberts.
The shot-stopper kicked the Frenchman in the side of the head as he tried to clear a bouncing ball, causing a horrible gash and seeing Mateta rushed off to hospital.
The forward posted on his Instagram story on Saturday evening about the injury and revealed he was okay, and Palace have also released a statement.
It reads: "We are very pleased to confirm that JP Mateta has this evening been discharged from St George's Hospital where he received specialist treatment and 25 stitches to a severe laceration to his left ear. All scans were clear and JP is feeling well.
"He will now rest and recuperate over the following days where his progress will be monitored by our club doctor.
"Thank you to the medical staff at both Selhurst Park and the hospital for their help and professionalism, and for all the wishes of support that JP and the club have received today."
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1st Mar 2025, 21:23By Jake Lambourne
Pep talk
Pep Guardiola was quick to praise Plymouth for their gutsy performance at the Etihad as he waxed lyrical over goalscorer Kevin De Bruyne.
Speaking after the 3-1 victory, the Spaniard said: "Big compliments to Plymouth for making our job so difficult. They were incredibly organised, but we played a good game - really good.
"We conceded a goal, but we were so solid. I'm really pleased with the game we played.
"No team has been in the [FA Cup] semi-finals five or six times in a row. Now we will fight, see the draw and see what happens."
On De Bruyne, who scored Manchester City's third, Guardiola remarked: "Maybe one of the best three to five players in this club's history.
"Every time he performs well I'm the happiest man on the planet. He's given many, many things to the team and to me, and he's played really, really well today.
"Nobody knows [where he will be next season]."
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1st Mar 2025, 20:53By Jake Lambourne
In Nic of time
Manchester City starlet Nico O'Reilly failed to contain his delight after his double helped dump Plymouth out of the FA Cup.
The 19-year-old scored a header in either half as the Citizens fought back to win 3-1 to seal their place in the quarter-finals.
Speaking to BBC Match of the Day after the victory, O'Reilly said: "It's an amazing feeling to score, especially at a club like this - the team I grew up playing for.
"It was a very tough game, very physical, very direct.
"We knew it was going to be and we tried to match it. We got the job done and I'm happy.
"I don't mind playing anywhere. Wherever the gaffer puts me, I'm happy with
"I want to get more minutes, keep my head down and keep going."
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1st Mar 2025, 19:41By Jack Johnson
Job done
That's it, Manchester City are through in the FA Cup.
They join Crystal Palace, Bournemouth and Preston in progressing through to the last eight today.
Pep Guardiola's side suffered a shock in the first half after conceding to Plymouth's only shot on goal in the entire game.
But they managed to fight back and the quality was too much for their Championship opponents in the end at the Etihad.
Here are all of today's FA Cup scores:
Crystal Palace 3-1 Millwall
Preston 3-0 Burnley
Bournemouth 1-1 (5-4 pens) Wolves
Manchester City 3-1 Plymouth
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1st Mar 2025, 19:35By Jack Johnson
GOAL! Man City 3-1 Plymouth: Kevin De Bruyne
That'll do it for Manchester City.
Erling Haaland turns provider for Kevin De Bruyne, passing across goal to give the Belgian a tap-in.
The hosts could have had a lot more but Plymouth have fought very hard to try and stay in this game.
It's painful for Argyle, but they can be proud.
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1st Mar 2025, 19:21By Jack Johnson
GOAL! Man City 2-1 Plymouth: Nico O'Reilly
MANCHESTER CITY FINALLY LEAD!
It's Nico O'Reilly who scores his second of the game! He heads home at the back post from a corner.
The hosts have completely deserved it, piling pressure onto the Plymouth defence for the entire game.
Erling Haaland and Bernardo Silva both missed from two yards out moments before the goal.
But the Championship side have finally been breached after Man City's 19th corner of this tie.
Less than 15 minutes to go and City lead for the first time.
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1st Mar 2025, 19:14By Jack Johnson
Inches away
Manchester City should be in front!
Somehow, Erling Haaland has missed a free chance at the back post, firing his first-time effort just over the bar.
That chance came after Plymouth goalkeeper Conor Hazard made a superb save to deny Kevin De Bruyne.
It's all Man City as it has been all game.
But the visitors are still level with 20 minutes to go.
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1st Mar 2025, 19:03By Jack Johnson
Time for Haaland
Here we go, Erling Haaland is on.
We're heading into the final half an hour and Manchester City are still being held by Plymouth.
But Haaland is going to make a difference.
This is his first cup appearance of the season.
Can he win the game for Man City? He'll certainly cause all sorts of problems for their Championshop opponents.
Plymouth have hardly had a touch and no shots since the break.
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1st Mar 2025, 18:49By Jack Johnson
Back underway
We're into the second half in Manchester.
Man City will be coming out to dominate just as they did in the first to try and find that second goal.
Going 1-0 down will have been embarrassing, especially when it was the only shot they'd conceded all game.
So they are going to want to kill this tie quickly.
If not, Plymouth remain in with a chance and what a massive upset that would be at the Etihad.
Ruben Dias has replaced Nathan Ake for City.
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1st Mar 2025, 18:33By Jack Johnson
GOAL! Man City 1-1 Plymouth: Nico O'Reilly
The Plymouth joy is short-lived!
Nico O'Reilly heads in an equaliser for Manchester City.
Kevin De Bruyne whips in a great free-kick and O'Reilly's header is too powerful for Conor Hazard to keep out.
That's the youngster's second FA Cup goal of the season.
And the half-time whistle blows moments later, as Plymouth just couldn't hold on until the break.
City have had 13 shots, 11 corners and 70 per cent of the ball.
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1st Mar 2025, 18:24By Jack Johnson
GOAL! Man City 0-1 Plymouth: Maksym Talovierov
CAN YOU BELIEVE IT?!
PLYMOUTH LEAD MANCHESTER CITY!
With their first shot on goal, the Championship strugglers have gone in front at the Etihad Stadium.
Matthew Sorinola's corner finds Maksym Talovierov and the big centre-back heads home with ease.
What a story this is! The away end is bouncing!
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1st Mar 2025, 18:16By Jack Johnson
Still goalless
Somehow, Man City are yet to score against Plymouth.
Ilkay Gundogan has just struck the post from inside the box as City continue to pile the pressure on.
They've had nine shots in the opening half an hour.
Plymouth haven't had any so far, and they're defending with their backs against the wall.
Every time they get a touch, which is a rare occasion, the away end are chanting 'Ole' for each pass.
They're definitely enjoying themselves at the Etihad!
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1st Mar 2025, 18:04By Jack Johnson
Bournemouth go through
Wow, what a penalty shootout!
Wolves were within one spot-kick from the win, but Matt Doherty missed to allow Bournemouth another chance.
And the Cherries didn't miss again, with Luis Sinisterra winning it after Boubacar Traore hit the crossbar.
It means Vitor Pereira's side miss out on the quarter-finals while Andoni Iraola's side are in the hat.
What a nightmare for Matheus Cunha, as his red card meant he couldn't take part in the shootout.
He'll also now solely miss Premier League games through suspension after his complete meltdown.
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1st Mar 2025, 17:49By Jack Johnson
Seeing red
Oh dear, Matheus Cunha.
The Wolves star has just been shown a straight red card for headbutting Milos Kerkez in the 120th minute.
Cunha looks to have completely lost his head, swinging his arms at the defender before butting heads with him.
He then continued to rage after being shown a red, refusing to leave the pitch and arguing with staff members and officials.
The Brazilian will now be suspended for three games.
Penalties are now ongoing to decide who progresses.
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1st Mar 2025, 17:45By Jack Johnson
Kick-off!
We're underway at the Etihad!
Plymouth, who knocked Liverpool out of the FA Cup in the fourth round, now take on Manchester City.
Can they take another monumental scalp?
Managed Miron Muslic told ITV pre-match: "This is the reward from Liverpool and we face the next giant of English football.
"The challenge cannot get bigger!
"It is a huge privilege to face Man City at the Etihad Stadium. It is a fantastic experience to have the Green Wall [Plymouth fans] here.
"We want our team to be brave."
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1st Mar 2025, 17:19By Jack Johnson
'It's pathetic'
Bournemouth and Wolves are now playing through extra-time after the game finished 1-1 at the Vitality.
So whilst that's ongoing, we'll take a look back to the controversial VAR incident that happened in the first half.