The Premier League leading Gunners will be hoping to get one over on their bitter rivals after Spurs, who pipped them to the final Champions League spot in May.
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Arteta's side have made a blistering start to the season with six wins from their opening seven games but Spurs have been in good form themselves and sit in third place - one point adrift.
With second-placed Manchester City not in action until Sunday, Arsenal or Spurs will be sitting pretty at the top of the table on Saturday night.
Former Tottenham midfielder Jamie O'Hara believes the game will be tight but it could be decided on coaching decisions.
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"I think the biggest thing in this game is going to be in the second half when the experience of Conte is going to get the better of Arteta," O'Hara told talkSPORT.
"You saw Arteta against Man United make substitutions and he got it wrong and he makes mistakes in big moments.
"Conte doesn't make them mistakes and he'll be watching this game and that's when I think the game will turn.
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"It's going to be a tight affair but once it gets into the second half and goes into the latter part of the game, Conte has got his number on Arteta - one million per cent."
Arteta's only blemish this season is the 3-1 reverse at Old Trafford at the start of September but his side's reaction to the defeat has been promising and sparked discussions of whether the Gunners can mount a serious title challenge this season.
Arsenal bounced back a fortnight ago with a convincing 3-0 at Brentford but the visit of Conte's side followed by Liverpool's trip to the Emirates next weekend will go a long way to determining their title credentials.
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Spurs will be buoyed by the return to form of forward Heung-Min Son who netted a hat-trick two-weeks ago in the 6-2 thrashing of Leicester City.
The South Korean carried on his good form by scoring twice for his country during the international break while Richarlison went one better, netting three times in Brazil's friendly wins over Ghana and Tunisia.
Tune into talkSPORT for LIVE and EXCLUSIVE commentary of Arsenal vs Tottenham in the Premier League, Saturday October 1, kick off: 12:30pm