The two teams will be meeting for the second time in the space of three days, the Blues prevailing 2-1 in Sunday's Premier League fixture at Stamford Bridge.
On this occasion, though, Enzo Maresca will take his squad - a much-changed one at that - to St James' Park to face a Magpies team that Eddie Howe has already acknowledged will not feature so many alterations.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of their long trip to the North-East as they bid to move closer to a second successive appearance in the final.
Omari Kellyman
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Omari Kellyman has suffered with fitness issues since joining from Aston Villa in the summer. The winger is currently sidelined with a hamstring injury with no date set for his return.
Reece James, Wesley Fofana, Romeo Lavia
Status: Out
Type of injury: Rested
Possible return date: November 3 (vs. Manchester United)
Maresca has previously indicated that Reece James, Wesley Fofana and Romeo Lavia will only play one game per week due to their previous injury issues. Given their appearances on Sunday, they will almost certainly be left out of the squad for this fixture.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspension issues heading into this contest.
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen