Spurs have not won a trophy since 2008and new boss Antonio Conte would love to change that by winning the inaugural Europa Conference League this season.
The north Londoners are second in Group G, three behind leaders Rennes with two games to go.
The group winners in the UECL will go through automatically but the runners-up will face a two-legged play-off in February.
Tottenham smashed Nura 5-1 in September and should get the job done again tonight ahead of key clash with Rennes next month.
Mura v Tottenham: Date and kick-off time
The Europa Conference League clash is set to take place on Thursday, November 25
It is taking place at the Stadion Ljudski vrt in Maribor, Slovenia and kick-off is set for 5:45pm UK time.
Spurs then host Rennes on December 9 in a match that could decide who will take top spot in Group G.
Mura v Tottenham: TV channel and live stream
The clash will be live on BT Sport 2 with coverage starting at 5:15pm.
BT Sport subscribers can live stream this match via the app on their computer, mobile and tablet devices.
Mura v Tottenham: Team news
Conte will make changes to his Tottenham side for the trip to Slovenia.
"All the players available will come with us," he said.
"They must be ready to play against Mura. I said on Sunday that I need to make rotation because there are players that are a bit tired because they played many games with the national team and also we worked a lot in the last two weeks.
"There are other players that need game time. For us this competition is important. We want to take this fixture seriously and we want to go through to the next step.
"For sure I will make the rotation because personally I need to know much better the players, because there are players I need to see during a game and a competition."
Cristian Romero is out while Giovani Lo Celso and Dane Scarlett remain sidelined.
Conte has confirmed that Ryan Sessegnon will start this evening.
Mura v Tottenham: What has been said?
Spurs boss Conte: "For us this competition is important. We want to take this fixture seriously.
"I know this is not simple, I am honest to understand this, but we want to try and build something important and try and lift trophies together, this must be our target.
"To build something ready to fight, in England it is not easy because the other teams are very, very strong but I know that through the work we can improve a lot.
"If you ask me how much time we need before it happens, it is very difficult to tell you this. In our heart and mind, this must be our inspiration and we are to try to do this for the best of the club."