The Reds have secured top spot in Group D with a game to spare and travel to Denmark tonight.
Midtjylland are bottom of the group and claimed their first ever Champions League point with a draw at Atalanta last week.
Liverpool beat Ajax last time out and manager Klopp will want to see his fringe players continue their good form tonight.
Midtjylland v Liverpool: How to listen
This Group D tie will get under way at 5:55pm on Wednesday, December 9.
Full coverage from the MCH Arena will be live on talkSPORT 2, with our coverage starting at 5pm.
Jim Proudfoot and Ray Houghton will be on commentary duty and to tune in, click the radio player below or HERE for the live stream.
Here are the other ways to listen…
App iPhone - Download from the Apple store
App Android - Download from Google Play
Radio - talkSPORT is available across the United Kingdom via DAB digital radio and on 1089 or 1053 AM.
TV - Listen to talkSPORT through your TV on the following channels: Sky: Channel 0108 Virgin Media: Channel 927 Freeview: Channel 723 Freesat: Channel 731
Midtjylland v Liverpool: Confirmed teams
The Reds have handed a start to midfielder Leighton Clarkson, while Trent Alexander-Arnold will captain the club for the first time.
Also making Klopp's XI for the game in Denmark are Divock Origi, Rhys Williams, and Takumi Minaminio, while Kostas Tsimikas comes into the side for Andrew Robertson.
FC Midtjylland: Hansen, Cools, Sviatchenko, Scholz, Paulinho, Cajuste, Onyeka, Dreyer, Evander, Mabil, Kaba.
Substitutes: Hoegh, Andersson, Sisto, Thorsen, Vibe, Ottesen, Pfeiffer, Anderson, Madsen, Dyhr, Isaksen, Sery.
Liverpool: Kelleher, Alexander-Arnold, Rhys Williams, Fabinho, Tsimikas, Minamino, Clarkson, Keita, Salah, Origi, Jota.
Subs: Wijnaldum, Firmino, Mane, Adrian, Henderson, Jones, Robertson, Matip, Jaros, Cain, Neco Williams, Koumetio.
Referee: Francois Letexier (France)
Midtjylland v Liverpool: What has been said?
Midtjylland coach Brian Priske admits expectations have been raised for the visit of Liverpool after earning their first Champions League point in last week's draw against Atalanta.
"Of course we do not know 100 per cent who Liverpool will line up with, but to start with, our focus is on ourselves," he said.
"We are all looking forward to the last match in this year's Champions League, which is also our last home game (of 2020).
"We will do everything to deliver a great result and actually expect a lot from ourselves after last week's experience against Atalanta.
"All our energy and strength is directed towards Liverpool tomorrow and the attempt to get three more points."
Midtjylland defender Erik Sviatchenko believes the experience of playing in their first Champions League campaign has been invaluable for the players.
"We had a good match the last time we met Liverpool (a 2-0 defeat at Anfield) and have generally gained a lot of good experience during the autumn," he said.
"If everyone works as one and does the things we are good at, we are hard to play against, and then we have good opportunities to take points against even the best."
Jurgen Klopp will have the chance to rotate his squad when Liverpool take on FC Midtjylland this evening.