The match will mark Erik ten Hag's first competitive fixture in charge of the 20-time English champions, who will be bidding to secure a spot in the top four this season, having finished down in sixth last term.
The Red Devils played twice last weekend as they brought their pre-season to a close, losing to Atletico Madrid in Oslo on Saturday before drawing 1-1 with Rayo Vallecano at Old Trafford on Sunday.
Here, Sports Mole rounds up the team's latest injury and suspension news ahead of the contest with Brighton, who beat Man United 4-0 in their penultimate match of last season.
Brandon Williams
Status: Major doubt
Type of injury: Unknown
Possible return date: August 7 (vs. Brighton)
Brandon Williams has not been involved for Man United during their pre-season preparations due to injury, and the full-back is not expected to be in the squad against the Seagulls even if he recovers from the issue.
Jadon Sancho
Status: Minor doubt
Type of injury: Illness
Possible return date: August 7 (vs. Brighton)
Jadon Sancho was forced to miss out against Atletico last Saturday due to illness, but the England international is widely expected to recover in time for Sunday's contest.
Luke Shaw
Status: Minor doubt
Type of injury: Illness
Possible return date: August 7 (vs. Brighton)
Luke Shaw was not involved against either Atletico or Rayo last weekend due to an illness, but like Sancho, the left-back should have recovered in time for the clash with the Seagulls.
Anthony Martial
Status: Major doubt
Type of injury: Hamstring
Possible return date: August 7 (vs. Brighton)
Anthony Martial has emerged as a major doubt for Man United's Premier League opener due to a hamstring problem that he picked up against Atletico last weekend.
MAN UNITED'S SUSPENSION LIST
Mason Greenwood remains suspended by the club until further notice.