The Red Devils recorded a 3-0 victory over West Ham United in the league last weekend, with the result moving them into sixth position in the Premier League table.
Erik ten Hag's side are now six points behind fifth-placed Tottenham Hotspur and eight behind fourth-placed Villa in the race to secure Champions League football for the 2024-25 campaign.
Here, Sports Mole rounds up Man United's latest injury and suspension news ahead of the clash with a Villa side who lost 3-1 at home to Chelsea in the FA Cup on Wednesday night.
Tyrell Malacia
Status: Out
Type of injury: Knee
Possible return date: Unknown
Malacia is now in individual training, as he bids to recover from a knee injury which has required two separate occasions, but he is not yet ready to return to action.
Mason Mount
Status: Out
Type of injury: Calf
Possible return date: Unknown
Mount has recently been back in individual training after recovering from a calf issue, but he will again be unavailable for selection on Sunday afternoon.
Lisandro Martinez
Status: Out
Type of injury: Knee
Possible return date: Unknown
Martinez will be out for a minimum of eight weeks with the knee injury that he suffered against West Ham last time out, with the Argentine therefore not available until at least the start of April.
Anthony Martial
Status: Out
Type of injury: Groin
Possible return date: Unknown
Martial, who has not featured for the Red Devils since the start of December, has undergone a groin operation which will sideline him until at least the end of March.
Aaron Wan-Bissaka
Status: Minor doubt
Type of injury: Knock
Possible return date: February 11 (vs. Aston Villa)
Wan-Bissaka was again absent against West Ham due to a knock, and it remains to be seen whether the defender is back in the squad for the clash with Villa.
MANCHESTER UNITED SUSPENSION LIST
Man United have no players suspended for Sunday's match.