The Citizens secured a slender 1-0 home victory in their last match against Spurs' rivals Arsenal in the FA Cup fourth round last Friday.
Pep Guardiola's men now return to Premier League action against a Tottenham side whom they beat 4-2 at the Etihad Stadium just over two weeks ago.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with Antonio Conte's side.
John Stones
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
John Stones pulled up with a hamstring injury in the first half of City's FA Cup fourth-round win over Arsenal last week and there is currently no timescale on his return to action.
Phil Foden
Status: Minor doubt
Type of injury: Foot
Possible return date: February 5 vs. Tottenham Hotspur
Phil Foden is a doubt after missing the last two matches with a foot injury and he is set to be assessed ahead of kickoff on Saturday.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.