The Citizens played out a pulsating 4-4 draw with Chelsea before the international break, with the result leaving them top of the table on 28 points, one point ahead of second-placed Liverpool.
Pep Guardiola's side have won nine, drawn one and lost two of their 12 league matches this season, and a victory on Saturday would allow them to open up a four-point advantage at the summit.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with Jurgen Klopp's team.
Kevin De Bruyne
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
De Bruyne has been on the sidelines since August due to a long-term hamstring problem, and the Belgium international will not be available for selection until January at the earliest.
John Stones
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Stones has been ruled out for a long period due to a muscular injury, and it is currently unclear when the England international could be available for selection.
Erling Haaland
Status: Minor doubt
Type of injury: Ankle
Possible return date: November 25 (vs. Liverpool)
Haaland withdraw from the Norway camp over the international break due to an ankle injury, but the centre-forward is widely expected to be available for selection this weekend.
Sergio Gomez
Status: Major doubt
Type of injury: Ankle
Possible return date: November 25 (vs. Liverpool)
Gomez recently suffered an ankle injury in training, and although he has not yet been ruled out of this match, it would be a surprise to see the defender in the squad.
Matheus Nunes
Status: Major doubt
Type of injury: Muscle
Possible return date: November 25 (vs. Liverpool)
Nunes was not involved for Portugal over the international break due to a muscular problem, meaning that he is a major doubt for the contest with Liverpool.
Ederson
Status: Minor doubt
Type of injury: Foot
Possible return date: November 25 (vs. Liverpool)
Ederson withdrew from the latest Brazil squad due to a foot problem that he suffered against Chelsea, but the goalkeeper is expected to be available for selection this weekend.
Mateo Kovacic
Status: Major doubt
Type of injury: Thigh
Possible return date: November 25 (vs. Liverpool)
Kovacic is a major doubt for the game with Liverpool due to the thigh problem that forced him to miss out for Croatia during the international break.
Nathan Ake
Status: Minor doubt
Type of injury: Knock
Possible return date: November 25 (vs. Liverpool)
Ake has recently been sidelined due to a knock, but there is a strong chance that the Netherlands international will be available to make his return in this match.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no suspended players for this match.