The Red Devils entered the October international break off the back of a goalless draw with Aston Villa, which left them down in 14th position in the Premier League table.
Erik ten Hag has kept his job as manager despite the team's struggles this term, but there will be major pressure on the Dutchman to oversee an improvement in the coming weeks.
Here, Sports Mole rounds up Man United's injury and suspension news ahead of their contest with Brentford, who recorded an eye-catching 5-3 victory over Wolverhampton Wanderers last time out.
Leny Yoro
Status: Out
Type of injury: Foot
Possible return date: December 3 (vs. Arsenal)
Yoro will be out until at least the start of December due to the fractured metatarsal that he suffered during a pre-season clash with Arsenal, with his debut for the club potentially coming against the Gunners in the Premier League.
Tyrell Malacia
Status: Out
Type of injury: Knee
Possible return date: Unknown
Malacia missed the entire 2023-24 season due to a serious knee injury which required two separate operations, and the left-back is still not ready to return, but he has recently stepped up his recovery and has a slight chance of being available before the end of the year.
Luke Shaw
Status: Major doubt
Type of injury: Calf
Possible return date: October 19 (vs. Brentford)
Shaw has been absent early in the season due to a calf problem; the left-back remains a major doubt for the visit of Brentford, but there is a slight chance that he could be back in the squad this weekend.
Noussair Mazraoui
Status: Out
Type of injury: Heart
Possible return date: Unknown
Mazraoui is currently recovering after undergoing a minor heart procedure, but Morocco's manager Walid Regragui has said that the left-back could be available for his country's November fixtures.
Kobbie Mainoo
Status: Minor doubt
Type of injury: Muscle
Possible return date: October 19 (vs. Brentford)
Mainoo was not risked in the recent Europa League clash against Porto due to a minor muscular issue; he did return to the side against Villa, but the midfielder pulled out of the England squad for their October fixtures to recover. Despite the injury scare, Mainoo is widely expected to be available for selection this weekend.
Mason Mount
Status: Major doubt
Type of injury: Head/knock
Possible return date: October 19 (vs. Brentford)
A head injury and a knock contributed to Mount missing out against Porto in the Europa League and Villa in the Premier League, but he has a chance of returning for this match.
Alejandro Garnacho
Status: Minor doubt
Type of injury: Knee
Possible return date: October 19 (vs. Brentford)
Garnacho did not travel with the Argentina squad for their October fixtures due to a minor knee problem, but the forward is set to be available for selection against Brentford.
Amad Diallo
Status: Minor doubt
Type of injury: Illness
Possible return date: October 19 (vs. Brentford)
Amad pulled out of the Ivory Coast during the international break due to an illness, but the attacker is expected to be in the squad against Brentford on Saturday afternoon.
Harry Maguire
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Man United will be without the services of central defender Maguire for the next "few weeks" due to the muscular problem that forced him off the field in the clash with Villa last time out.
MANCHESTER UNITED'S SUSPENSION LIST
Man United have no players suspended for the Premier League clash.