Marcus Rashford is once again left out for the Red Devils, with the forward not involved for the third match in a row after expressing a desire to leave the 20-time English champions.
Alejandro Garnacho, like Rashford, was left out of the squad for the Manchester derby last weekend, but the Argentine returned against Tottenham Hotspur in the EFL Cup on Thursday night and is again on the bench.
Amorim has made six changes to the side that started against Spurs, with Harry Maguire, Andre Onana, Kobbie Mainoo, Tyrell Malacia, Amad Diallo and Joshua Zirkzee coming into the XI.
Rasmus Hojlund and Leny Yoro are among those to drop to the bench for the 20-time English champions.
As for Bournemouth, head coach Andoni Iraola has made one change to the side that started the 1-1 draw with West Ham United last time out, with Tyler Adams coming in for Lewis Cook.
Justin Kluivert is the team's top goalscorer this season, scoring five times in all competitions, and the 25-year-old will once again feature in the final third of the field.
MAN UNITED: Onana; Mazraoui, Maguire, Martinez; Dalot, Ugarte, Mainoo, Malacia; Amad, Zirkzee, Fernandes
Subs: Bayindir, Evans, Yoro, Casemiro, Collyer, Eriksen, Antony, Garnacho, Hojlund
BOURNEMOUTH: Kepa; Smith, Zabarnyi, Huijsen, Kerkez; Adams, Christie; Semenyo, Kluivert, Ouattara; Evanilson
Subs: Travers, Cook, Brooks, Hill, Unal, Philip, Aarons, Winterburn, Kinsey
Written by
Matt Law