Ince's Reading will be aiming to pull off shock result against the in-form Red Devils and a firing Marcus Rashford on Saturday evening.
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Erik ten Hag's side, who beat Everton in the last round, have only lost one game in their last 12 and they will be keen to continue their journey this weekend.
The key player for United has been Rashford who has scored 10 goals in 10 games since the World Cup.
The Royals will be hoping the in-form man ends his scoring streak as manager Ince heads back to Manchester.
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The 55-year-old made 206 appearances for the Red Devils, winning the Premier League and FA Cup twice as a player, but he will be out to end their cup run this time around.
Manchester United vs Reading: talkSPORT coverage
This FA Cup fourth round tie will take place on Saturday, January 28.
Kick-off at Old Trafford is scheduled for 8pm.
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talkSPORT will have live coverage of the game presented by Faye Carruthers.
Commentary will then come from Adam Bridge and former England defender Micky Gray.
While talkSPORT.com will also be running a live blog of all the action.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
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You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Manchester United vs Reading: Team news
Jadon Sancho made his return to training for United last week and could play a part at Old Trafford on Saturday.
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Axel Tuanzebe may also be a part of the Red Devils squad after recovering from an injury which has left him out of action since July.
As for Reading, Chelsea loanee Baba Rahman is likely to start at left-back with Jeff Hendrick, who is on loan from Newcastle, in midfield.
Andy Carroll missed their defeat to Stoke last time out through injury and may not be available for this FA Cup clash.
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Manchester United vs Reading: What has been said?
Reading boss Ince has praised Ten Hag and the job he has done at United ahead of their meeting this weekend.
Ince said: "It looks to me as if he has risen the standards. He is doing it his way which is so important. It helps when you're winning games and have got a lot of money to spend.
"He has brought in the right players. For so many years we've talked about United's recruitment. I feel like he is getting there with the players has brought in.
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"They are all starting to gel and that breeds confidence. When you go back to Sir Alex Ferguson and his success, it's so important to have that stability.
"You can't keep chopping and changing managers anywhere. United have done that too often in the last four or five years. Hopefully, he is there for a long time."
Manchester United vs Reading: Match facts
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Man Utd's Marcus Rashford has been involved in five goals in his last five FA Cup appearances (2 goals, 3 assists). His only brace in the competition to date came against Reading in January 2017.
Reading have lost seven of their last eight FA Cup matches against Premier League opponents, with the other a 3-1 home win against West Brom in February 2016.
Manchester United are unbeaten in their last 14 home games in the FA Cup (W12 D2) since a 2-1 defeat to Arsenal in 2015. They have lost just one of their last 39 home games against sides from outside the top-flight (W31 D7), a 1-0 defeat to Leeds United in January 2010.
Reading have won just one of their 22 matches against Man Utd in all competitions (D7 L14) and have lost their last six in a row. Their only win against the Red Devils was in January 1927 in a second replay at the third round stage of the FA Cup, a game played at Villa Park.
Manchester United have progressed from nine of their 10 FA Cup ties against Reading, only failing in the third round in the 1926-27 season.