The Red Devils have been knocked out of every cup competition this season and are 20 points off the top of the table, so all they have left to play for is the Champions League places.
United are currently four points behind Arsenal and one off Tottenham, but the Gunners have a game in hand on the Red Devils.
Meanwhile, Leicester's season is looking like it's going to fizzle out.
The Foxes are ten points behind Wolves in seventh and their only hope of European football rests with the Europa Conference League.
However, the Foxes are looking to do the 'double' over United after a 4-2 win at the King Power earlier this season.
That game was probably one of Leicester's best displays this term but inconsistency and injuries have killed their league campaign.
Man United v Leicester: talkSPORT coverage
This Premier League clash will take place at Old Trafford on Saturday, April 2 and will kick off at 5:30pm.
Commentary will come from Clive Tyldesley and former West Ham United forward Trevor Sinclair.
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Man United v Leicester: Team news
United appear to have a full squad to choose from ahead of the game at Old Trafford on Saturday.
But they do have a lot of players on international duty, so they will hope they don't pick up any injuries between now and the weekend.
Cristiano Ronaldo will likely be involved in Portugal's World Cup play-off final against North Macedonia on Tuesday, while several other players will also be involved in important games for their countries.
Both Uruguay and Brazil play World Cup qualifiers early Wednesday morning, so there isn't a lot of time for Fred, Alex Telles and Edinson Cavani to fly, rest and train before the match.
Leicester are likely to be without at least three players for the trip to Old Trafford, with Wilfried Ndidi, Danny Ward and Ryan Bertrand struggling.
Ndidi suffered a medial ligament injury that could keep him out for the season, while Ward and Bertrand have had surgery to fix knee problems.
However, there is better news for Jonny Evans, Jamie Vardy and Wesley Fofana.
Evans made an appearance as a substitute against Brentford before the international break and played for Northern Ireland on Friday night.
Vardy is expected back in training this week after a hamstring injury and Fofana played 70 minutes against Rennes in the UECL.
So, things are looking a lot better for Leicester on the injury front.