The Red Devils lost to Aston Villa last time out in the top-flight while Everton will be hoping to leap frog their opponents with the winner of this clash set to go top.
Everton beat Norwich 2-0 in their last game but still have quite a few injuries to contend with.
Andros Townsend stepped up to help the Toffees secure victory last weekend and could be vital to a squad without key forwards.
Ole Gunnar Solskjaer has been boosted by a dramatic late win against Villarreal in the Champions League on Wednesday thanks to a Cristiano Ronaldo winner.
Man United team news
Solskjaer had to deal with two new injuries to captain Harry Maguire and Luke Shaw over the past week.
Maguire missed the Champions League clash during the week and his calf injury is set to keep him out for a few weeks.
Shaw also sat out of Wednesday's match but could return against Everton after a knock resulted in the full-back being substituted in the first-half against Aston Villa last weekend.
United still have two long-term injuries to Amad Diallo and Marcus Rashford, who could be returning as soon as next month.
Everton team news
The injury to Dominic Calvert-Lewin is a big blow to Everton and he is still out after scoring three in three matches at the start of the season.
Cenk Tosun has been a long-term absentee but should return at some point in October, but the United game will be too soon to see him feature.
Seamus Coleman, who has a hamstring injury, and Richarlison, who has been out of the last two Premier League matches, should both be back after the international break.
Andre Gomes has a calf injury and it is unknown when he will make a return to the squad.
Fabian Delph is expected to be back at the start of November as he recovers from a shoulder problem.