And next up is a visit from Crystal Palace after the Red Devils secured their place in the Carabao Cup final to face Newcastle.
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United's winning run was ended by Palace last month in south London and Erik ten Hag's men must take three points this weekend.
The race for the top four is well and truly on, with Newcastle and Man United on 39 points and Tottenham on 36, so any draws or defeats could prove costly.
But the Red Devils can take comfort from their ridiculous home record that has seen them win their last five league games and they are unbeaten at Old Trafford in the league since the opening day defeat to Brighton.
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However, they have struggled against Palace in recent times and have failed to win their last two and only won one of the last five.
The last time they didn't beat the south Londoners for three consecutive games was in 1970, and they will be keen to avoid that happening again.
United are set for a monster month and every fixture is important, so they can't afford any slip up.
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But they will be without Christian Eriksen until at least April after he was injured in the FA Cup against Reading.
Marcel Sabitzer arrived as a late loan signing from Bayern Munich and might find himself thrust straight into the action against an aggressive Eagles side.
Palace aren't in the best form, having won just one of their last seven in the league.
But they are good at finding a way to pick up points, having drawn six matches so far, which is a number only surpassed by Newcastle and Brentford (nine each).
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A draw on Saturday would be a good result for Palace - although they will be trying to win the game.
But a point shared for Ten Hag's Red Devils could be a nightmare for their top-four hopes.
Since the mid-season break, United have been in great league form but a loss and a draw in their last two has slightly slowed that momentum, meaning Saturday is a very important game.
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But the Eagles, under Patrick Vieira's guidance, are stubborn and have enjoyed good times against Man United in recent years, meaning we are all set for an absolute cracker.