The Citizens, sitting top of the table and two points clear of rivals Arsenal in second, know that victory against the Hammers will be enough to clinch a record fourth consecutive top-flight title.
Guardiola has been enforced to make one change to the side that beat Tottenham Hotspur 2-0 on Tuesday, with goalkeeper Ederson - who is sidelined with a fractured eye socket - replaced by Stefan Ortega.
The other alteration sees midfielder Mateo Kovacic make way for Jeremy Doku, who is expected to start on the left side of attack.
A back four of captain Kyle Walker, Manuel Akanji, Ruben Dias and Josko Gvardiol remains intact, with midfield lynchpin Rodri set to operate just in front.
Doku will be joined in the final third by Bernardo Silva, Kevin De Bruyne and Premier League Player of the Season Phil Foden, with leading marksman Erling Haaland starting up front.
As for West Ham, David Moyes - in his final match as Hammers manager - has also made two changes to the team that beat Luton Town 3-1 last time out, with Konstantinos Mavropanos and Aaron Cresswell both recalled, joining Vladimir Coufal, Kurt Zouma and Emerson Palmieri in what is expected to be a back five.
Angelo Ogbonna drops to the substitutes' bench, while top scorer Jarrod Bowen has been left out of the matchday squad due to illness.
James Ward-Prowse and Tomas Soucek and Lucas Paqueta are set to form a three-man midfield, with the latter also linking up in attack with Mohammed Kudus and Michail Antonio.
Manchester City: Ortega; Walker, Akanji, Dias, Gvardiol; Rodri; Bernardo, De Bruyne, Foden, Doku; Haaland
Subs: Carson, Stones, Ake, Kovacic, Grealish, Alvarez, Nunes, Bobb, Lewis
West Ham United: Areola; Coufal, Zouma, Mavropanos, Cresswell, Emerson; Ward-Prowse, Soucek, Paqueta; Kudus, Antonio
Subs: Fabianski, Johnson, Casey, Ogbonna, Alvarez, Earthy, Cornet, Ings, Mubama
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen