The Citizens are eight-time winners of the tournament, while the Hornets have already beaten MK Dons and Plymouth Argyle to make it this far, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER CITY vs. WATFORD
MANCHESTER CITY
Out: Kevin De Bruyne (groin), Rodri (knee), Oscar Bobb (leg), Nathan Ake (thigh)
Doubtful: None
Sports Mole's predicted XI: Ortega; Lewis, Stones, Simpson-Pusey, Wilson-Esbrand; Nunes, Wright; O'Reilly, McAtee, Grealish; Foden
WATFORD
Out: Kevin Keben (knee), Daniel Bachmann (muscle), Francisco Sierralta (muscle), Daniel Jebbison (cup-tied), Ryan Andrews (hamstring)
Doubtful: None
Sports Mole's predicted XI: Bond; Morris, Pollock, Porteous; Ebosele, Dele-Bashiru, Sissoko, Sema; Chakvetadze, Baah; Bayo
For data analysis of the most likely results, scorelines and more for this match please click here.