The Citizens are having to cope without top scorer Erling Haaland, who has been ruled out for five to seven weeks with an ankle injury sustained in Sunday's 2-1 comeback victory over Bournemouth in the FA Cup quarter-finals.
Omar Marmoush scored the winner just three minutes after coming off the substitutes' bench to replace Haaland at the Vitality Stadium and the Egyptian January signing is set to lead the line for Man City.
Nico O'Reilly has been rewarded for his Man of the Match second-half display against Bournemouth with his first Premier League start and just third top-flight appearance of his senior career, while Nico Gonzalez, Savinho, Jeremy Doku and Jack Grealish are also recalled.
Goalkeeper Ederson will be protected by a four-man backline of Matheus Nunes, Ruben Dias, Josko Gvardiol and O'Reilly. Abdukodir Khusanov has made way for the latter and has bene left out of City's matchday squad.
Gonzalez will link arms in midfield with Ilkat Gundogan and Jack Grealish is also set to operate in a central role as Savinho and Doku provide support from the flanks for Marmoush up top.
Manwhile, Oscar Bobb has made a welcome return to the senior matchday squad for the first time since fracturing a bone in his leg back in August last year.
More to follow.
Written by
Oliver Thomas
Napoli 
Empoli 
Atletico Madrid 
Valladolid 
Lokomotiv Moscow 
Akhmat Grozny 
Spartak Moscow 
Ural 
Aston Villa 
Paris Saint Germain 
Borussia Dortmund 
Barcelona 
Kryvbas Kryvyi Rih 
Shakhtar Donetsk 
Dinamo Moscow 
CSKA Moscow 
Inter 
Bayern Munich 
Real Madrid 
Arsenal 
Fiorentina 
NK CM Celje 
Athletic Bilbao 
Rangers 
Eintracht Frankfurt 
Tottenham 
Lazio 
Bodo/Glimt 
Manchester Utd 
Lyon 
Chelsea 
Legia Warszawa 
Dynamo Kyiv 
Obolon-Brovar Kyiv 
FC Porto 
Famalicao 
Bordeaux 
Valenciennes 
Espanyol 
Getafe 
Akron Togliatti 
Rayo Vallecano 
Valencia 
FC Heidenheim 
FSV Mainz 05 
VFL Wolfsburg 
Werder Bremen 
VFL Bochum 
Everton 
Manchester City 
Nizhny Novgorod 
Celta Vigo 
LE Havre 
Kolos Kovalivka