The Citizens were forced to settle for just a point in a 1-1 draw with Newcastle United last weekend, but they returned to winning ways with a comfortable 4-0 victory against Slovan Bratislava in the Champions League on Tuesday.
Fulham, meanwhile, have won their last two Premier League games, including a narrow 1-0 victory at Nottingham Forest last weekend, helping them climb up to sixth in the table and just three points behind Man City in second.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 74
Man City wins: 41
Draws: 16
Fulham wins: 17
Man City and Fulham have faced each other a total of 74 times across all competitions, with the Citizens leading the overall head-to-head record having posted 41 wins to the Cottagers' 17, while 16 draws have been played out between the two clubs.
February 1908 was the very first time that these two clubs butted heads in the third round of the FA Cup, with a 1-1 draw at Hyde Road followed by Fulham winning the replay 3-1 at Craven Cottage. Man City failed to win their first three meetings with the Cottagers, but celebrated success for the first time in 1910 when they secured a 3-1 home win in the old Division Two.
Both Man City and Fulham had their fair share of successes during their regular battles in Divisions One and Two over the years, but in the Premier League era (since 1992-93), the former have truly dominated this fixture.
Indeed, the Citizens have won 19 of their 32 Premier League encounters with Fulham, coming out on top by a margin of at least two goals on 14 occasions, while they have also kept 10 clean sheets during this run.
Fulham enjoyed their best spell against City in the top flight between 2003 and 2009 when they accumulated 18 points across 12 games, winning four and drawing six. However, a 3-1 triumph at the Etihad in April 2009 was the last time that they beat the Citizens in any competition to date.
Man City have won each of their last 16 meetings with Fulham across all competitions - the longest winning run one team has had over another in English football league history.
The Citizens boast a 100% record against Fulham under the tutelage of Pep Guardiola, who led his team to a 5-1 home win and a 4-0 away victory in the 2023-24 Premier League campaign.
Man City legend Sergio Aguero is the all-time leading scorer in this fixture with six goals in eight games, while Erling Haaland is next on the list with five goals in just four appearances versus Fulham.
Previous meetings
May 11, 2024: Fulham 0-4 Man City (Premier League)
Sep 02, 2023: Man City 5-1 Fulham (Premier League)
Apr 30, 2023: Fulham 1-2 Man City (Premier League)
Nov 05, 2022: Man City 2-1 Fulham (Premier League)
Feb 05, 2022: Man City 4-1 Fulham (FA Cup Fourth Round)
Mar 13, 2021: Fulham 0-3 Man City (Premier League)
Dec 05, 2020: Man City 2-0 Fulham (Premier League)
Jan 26, 2020: Man City 4-0 Fulham (FA Cup Fourth Round)
Mar 30, 2019: Fulham 0-2 Man City (Premier League)
Nov 01, 2018: Man City 2-0 Fulham (EFL Cup Fourth Round)
Sep 15, 2018: Man City 3-0 Fulham (Premier League)
Mar 22, 2014: Man City 5-0 Fulham (Premier League)
Dec 21, 2013: Fulham 2-4 Man City (Premier League)
Jan 19, 2013: Man City 2-0 Fulham (Premier League)
Sep 29, 2012: Fulham 1-2 Man City (Premier League)
Feb 04, 2012: Man City 3-0 Fulham (Premier League)
Sep 18, 2011: Fulham 2-2 Man City (Premier League)
Feb 27, 2011: Man City 1-1 Fulham (Premier League)
Nov 21, 2010: Fulham 1-4 Man City (Premier League)
Mar 21, 2010: Fulham 1-2 Man City (Premier League)
Last 10 Premier League meetings
May 11, 2024: Fulham 0-4 Man City (Premier League)
Sep 02, 2023: Man City 5-1 Fulham (Premier League)
Apr 30, 2023: Fulham 1-2 Man City (Premier League)
Nov 05, 2022: Man City 2-1 Fulham (Premier League)
Mar 13, 2021: Fulham 0-3 Man City (Premier League)
Dec 05, 2020: Man City 2-0 Fulham (Premier League)
Mar 30, 2019: Fulham 0-2 Man City (Premier League)
Sep 15, 2018: Man City 3-0 Fulham (Premier League)
Mar 22, 2014: Man City 5-0 Fulham (Premier League)
Dec 21, 2013: Fulham 2-4 Man City (Premier League)
Read more on Manchester City vs Fulham
De Bruyne, Rodri, Ake latest: Man City injury list for Fulham clash
Click here to read our full preview for Manchester City vs Fulham
Guardiola to reshuffle his midfield? Predicted Man City lineup vs. Fulham
Berge, Reed pushing for recall? Predicted Fulham lineup vs. Man City