Victory for the fourth-placed Lions would cut their deficit to Pep Guardiola's men down to just two points, although the hosts still have a game in hand, and here Sports Mole rounds up the team news for both clubs.
MANCHESTER CITY vs. ASTON VILLA
MANCHESTER CITY
Out: Ederson (thigh), Kyle Walker (thigh)
Doubtful: Nathan Ake (unspecified)
Sports Mole's predicted XI: Ortega; Lewis, Dias, Akanji, Gvardiol; Rodri, Kovacic; Doku, De Bruyne, Grealish; Haaland
ASTON VILLA
Out: John McGinn (suspended), Tyrone Mings (knee), Boubacar Kamara (knee), Emiliano Buendia (knee), Matty Cash (thigh)
Doubtful: Ollie Watkins (hamstring), Jacob Ramsey (ankle)
Sports Mole's predicted XI: Martinez; Konsa, Carlos, Torres, Digne; Bailey, Luiz, Tielemans, Rogers; Diaby, Duran
For data analysis of the most likely results, scorelines and more for this match please click here.