Both teams have four wins and two draws so far this term and go into the clash one point behind league leaders Arsenal.
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City drew at Aston Villa last weekend but hit back by smashing Sevilla in the Champions League.
Tottenham, meanwhile, have enjoyed a fine week having backed up their league success over Fulham with a fine win over Marseille in Europe.
These two produced a classic last season as Spurs clinched victory in a 3-2 thriller thanks to Harry Kane's 95th-minute header.
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Pep Guardiola and Antonio Conte will both be eager to secure the points this weekend and claim top spot in the table.
Man City v Tottenham: Date and how to follow
This Premier League clash will take place on Saturday, September 10.
Kick-off at the Etihad is at 5:30pm.
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The match will be broadcast on Sky Sports Main Event and Sky Sports Premier League, with coverage starting at 5pm.
Alternatively, fans can purchase a one-day Now TV pass for £11.99.
talkSPORT will have updates from the game all evening while talkSPORT.com will be running a live blog for all the action.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream. You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Man City v Tottenham: Team news
Kyle Walker is a major doubt for Man City while John Stones is struggling with a muscle injury too.
Fellow defender Aymeric Laporte is definitely out which means Manuel Akanji or Sergio Gomez could make their first Premier League starts for the club.
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Kalvin Phillips is also looking for his first start of the season.
Tottenham have no new issues to contend with as only Lucas Moura remains out.
Ivan Perisic should return to the starting line-up while Djed Spence is still awaiting his first league start.
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Man City v Tottenham: Match facts
Man City manager Pep Guardiola has lost six of his 15 meetings with Tottenham in all competitions (W7 D2) - he's only lost more often against Chelsea (8) and Liverpool (7) in his managerial career.
Manchester City have the highest shot conversion rate in the Premier League this season (19.6%). The Citizens have also outperformed their expected goals more than any other side this term, netting 20 goals compared to an xG of 13.9 (+6.1).
Victory for Tottenham would see them finish the day top of the Premier League table - it would be the latest into a top-flight season that Spurs have replaced north London rivals Arsenal at the top since 1984-85 (10th game).
Manchester City have won their last seven Premier League home games, scoring at least three goals each time. The last team to win eight straight top-flight home games while scoring 3+ goals were Tottenham between March and September 1965.
Tottenham have won four of their last nine away league games against reigning top-flight champions (D2 L3), as many as they had in their previous 49 such games. Four of Man City's 29 defeats as reigning Premier League champions have come against Tottenham - no side has beaten them more.
Tottenham won home and away against Manchester City in the Premier League last season, accounting for 67% of the Citizens' total league defeats. They could become the first ever team to win three consecutive league games against a side managed by Pep Guardiola.
Manchester City have lost four of their last five Premier League games against Tottenham (W1), as many as they had in their previous 19 against them (W12 D3).
No player has had more shots without scoring in the Premier League this season than Tottenham's Son Heung-min, with last season's Golden Boot winner having 17 attempts without success so far.
Erling Haaland has scored a hat-trick in each of his last two Premier League home games for Man City, doing so against Crystal Palace and Nottingham Forest. No player has scored a hat-trick in three consecutive Premier League home games before, while the last player to score as many as three home hat-tricks in a single campaign was Sergio Aguero in 2018-19.
Man City manager Pep Guardiola has lost three of his five meetings with Tottenham's Antonio Conte in all competitions (W2) - among managers he's faced at least five times in his career (excl. Barcelona B), Conte is the only one he's lost more than half of his games against (60%).