Current champions City are second in the table, five points behind leaders Arsenal, but with two games in hand.
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Pep Guardiola's side swept aside Sheffield United 3-0 in the FA Cup semi-final on Saturday, already armed with the knowledge that the Gunners had lost further ground in the title race.
Mikel Arteta's Arsenal have drawn three in a row, most recently scraping a 3-3 draw with bottom club Southampton.
City on a run of 16 games with a defeat and have won their last 11 Premier League meetings with Arsenal, including all six at the Etihad under Guardiola.
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Man City v Arsenal: talkSPORT coverage
This Premier League clash will take place on Wednesday, April 26.
Kick-off at the Etihad Stadium is scheduled for 8pm.
talkSPORT will have live and EXCLUSIVE coverage of the game presented by Adrian Durham.
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Commentary will then come from Sam Matterface, former City manager Stuart Pearce and ex-Arsenal winger Perry Groves.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream.
You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
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Man City v Arsenal: Team news
Nathan Ake is set to undergo a late fitness check after missing out the win over the Blades with a slight hamstring problem.
City otherwise have a clean bill of health with Kevin De Bruyne, Ruben Dias, Ederson and Rodri all rested at Wembley over the weekend.
The big story for the visitors is that William Saliba is set to miss out on the trip to Manchester after failing to recover from a back issue.
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Arsenal are already without long-term absentees Mohamed Elneny and Takehiro Tomiyasu but Granit Xhaka will be back from illness.
Man City v Arsenal: What has been said?
The Gunners could get beaten by 'three or four goals' against City following their 'embarrassing' display against Southampton.
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Speaking on talkSPORT's Gameday Phone-In, Gabby Agbonlahor said: "First of all, the huddle was embarrassing.
"Zinchenko, concentrate on your game. Doing the huddle for the cameras, you don't follow your runners, the set piece for the third goal you don't follow your man and concede.
"That, for a start, was embarrassing.
"For me, Rob Holding is a Championship defender. Not good enough to be third choice at a team who want to win the title.
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"Since Saliba has been injured they've conceded nine goals in five games - three draws in a row, that's not championship form.
"Vieira is not good enough. He looked lost - not good enough, Gabriel looks shaky and has got mistake in him, Jesus's finishing was shocking, Thomas Partey was poor too, giving easy passes away.
"I think that Man City will put three or four past this Arsenal team on Wednesday, I really do.
"He'll play Mahrez or Bernardo Silva on Zinchenko - Haaland will be in the changing room now saying, 'guys I can't wait to play against Holding and Gabriel'."
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Man City v Arsenal: Match facts
Gabriel Martinelli has been involved in 11 goals in his last 10 Premier League games for Arsenal (8 goals, 3 assists). Overall, he has 15 Premier League goals this season, the joint-most by a Brazilian player in a single campaign, along with Roberto Firmino in 2017-18.
Erling Haaland has scored 32 Premier League goals for Manchester City this season, the joint-most ever by a player in a 38-game campaign in the competition. 20 of these goals have come at the Etihad Stadium, the most home goals by a player in a season since 2007-08 when Cristiano Ronaldo (Old Trafford) and Fernando Torres (Anfield) each scored 21.
Bukayo Saka has scored Arsenal's last two Premier League goals against Man City, though both of these have come in home games. The last Arsenal player to score home and away against Man City in the same season was Theo Walcott in 2016-17.
Arsenal boss Mikel Arteta has lost all six of his Premier League games against Man City - they're the only side the Spaniard has faced but failed to beat as a manager in the competition.
Arsenal have conceded at least twice in six of their last 11 Premier League games, including each of the last three in a row - they'd only conceded multiple goals five times in their first 21 this season. However, they've also scored at least twice in each of their last eight league games, last having a longer such run between August-October 2018 (9).
Manchester City have won eight of their last nine Premier League games, including their last six in a row. At home they've won 17 of their last 19 league games (D1 L1), though their last four defeats at the Etihad have been against London sides (Chelsea, Crystal Palace, Tottenham and Brentford).
Man City have beaten Arsenal twice this season, winning 3-1 in the Premier League and 1-0 in the FA Cup. They've already beaten the Gunners three times in a single season twice before (2017-18 and 2020-21) - only Liverpool have ever beaten them three times in three different campaigns (1994-95, 1996-97 and 2021-22).
Arsenal have scored just three goals in their last 10 Premier League games against Man City, failing to score on seven occasions. They'd only failed to score in six of their previous 37 against the Citizens in the competition.
Arsenal have lost their last 11 Premier League games against Man City, their longest losing streak against an opponent in their league history.
Man City have won all six of their Premier League home games against Arsenal under Pep Guardiola by an aggregate score of 17-3. They last lost at home to the Gunners in January 2015 (0-2).