The two teams finished runners-up in their domestic leagues last season, and both are intent on making it all the way to this term's new-look group stage.
Match preview
Unveiled as Fenerbahce's latest manager to much fanfare last month, Jose Mourinho was partly appointed on the basis of his superb track-record in European competition, having won all three of UEFA's club trophies during a glittering career.
Sacked by Roma midway through the 2023-24 campaign, the Portuguese coach now aims to prove his best days are not consigned to the past, taking on the challenge of steering Fener into the Champions League proper and wresting the Turkish title away from Istanbul rivals Galatasaray.
It has been over a decade since they lifted the Super Lig trophy, and despite posting 99 points last term - winning 31 times and losing just once - they still missed out to their bitterest foes.
Fener also lost to eventual winners Olympiacos in the Europa Conference League quarter-finals, but Mourinho's arrival has reignited ambitions of stepping up a gear during the coming campaign.
After three wins from five pre-season friendlies - including last week's 5-1 crushing of Hull City at Sukru Saracoglu Stadium - the Yellow Canaries now aim to take their first step towards a Champions League return, with three qualifying rounds still separating them from the group phase.
Last season's Swiss Super League runners-up stand in Fener's way, though, and Lugano started the 2024-25 season with a morale-boosting home victory over Grasshopper Zurich at the weekend.
Uran Bislimi's stoppage-time strike ultimately separated the sides at Stadio Cornaredo, but the Bianconeri will host their European fixtures at Thun's Stockhorn Arena for at least the next two years.
Mattia Croci-Torti's team had lost their final friendly to Italian champions Inter Milan, but they also beat Bellinzona and Parma during pre-season and are embarking on another quest to secure the Swiss title.
Last term's attempt was undermined by a leaky back line, and Lugano have finished runners-up more times (six) than they have claimed the crown (three).
They hope to finally end a 75-year wait this year, but first the minor matter of tackling a Turkish giant awaits; and after finishing rock-bottom of their Conference League group in 2023-24, the Bianconeri are outsiders to progress.
Lugano form (all competitions):
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Fenerbahce form (all competitions):
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Team News
Fenerbahce's Conference League campaign was spearheaded by Michy Batshuayi with four goals, but the Belgian striker has since made a controversial switch to Galatasaray; nonetheless, Jose Mourinho has plenty of fresh faces to call upon.
Youssef En-Nesyri is apparently weighing up whether to join Fener or Mourinho's old club Roma, but Allan Saint-Maximin has already been secured on loan, with Caglar Soyuncu, Rade Krunic and Levent Mercan also signing on the dotted line this summer.
The visitors should name veteran striker Edin Dzeko up front following his two goals against Hull; Fred and Sebastian Szymanski were also on target last time out, and both should start in Switzerland.
Lugano, meanwhile, are expected to field a similar XI to that which defeated Grashoppers in Saturday's Swiss Super League opener: Ignacio Aliseda occupies the centre-forward role, supported by Yanis Cimignani and captain Mattia Bottani.
After making his debut at the weekend, former Thun playmaker Daniel Dos Santos will be in contention for a place in midfield; however, Kosovan striker Shkelqim Vladi is ruled out by injury and Swiss international Renato Steffen has been given extended leave after featuring at Euro 2024.
Lugano possible starting lineup:
Saipi; Brault-Guillard, Mai, El Wafi, Valenzuela; Belhadj, Doumbia; Bislimi, Bottani, Cimignani; Aliseda
Fenerbahce possible starting lineup:
Livakovic; Osayi-Samuel, Soyuncu, Djiku, Mercan; Krunic, Fred; Tadic, Szymanski, Kent; Dzeko