Under-fire manager Julen Lopetegui will be expected to make a number of alterations for the contest, and he is expected to have a full squad available barring Niclas Fullkrug, who is still dealing with a calf problem.
The visiting coach could alter his attack regardless, as Michail Antonio is pushing to come back in and lead the line, possibly at the expense of Crysencio Summerville, whose withdrawal sparked boos from the London Stadium crowd at the weekend.
Antonio's possible recall could see Jarrod Bowen revert to a wide role, as Lucas Paqueta and Mohammed Kudus complete an experienced attacking contingent, although Luis Guilherme is a wild card candidate.
Neither Guido Rodriguez nor Edson Alvarez covered themselves in glory at the weekend - the former did not even make it to half time - so Tomas Soucek and Carlos Soler could link arms in the middle this time around.
A couple of members of the old guard should return to the backline too, as 39-year-old Lukasz Fabianski is set to take Alphonse Areola's place in goal, while Vladimir Coufal could return at right-back.
Summer signing Jean-Clair Todibo will likely be given the chance to impress in defence too, but Max Kilman and Emerson Palmieri's spots are surely secure, unless Merseyside native Aaron Cresswell earns a rare start against his former youth team.
West Ham United possible starting lineup:
Fabianski; Coufal, Todibo, Kilman, Emerson; Soler, Soucek; Bowen, Paqueta, Kudus; Antonio