Liverpool are coming into this match on the back of a huge Champions League victory over Porto on Tuesday.
The host's front line were in fine form as Mohamed Salah, Sadio Mane and Roberto Firmino were amongst the goals in a 5-1 thrashing over the Portuguese side.
Man City however lost to a star-studded Paris Saint-Germain side but did overcome a strong Chelsea defence with a strong performance in their league win last weekend.
Liverpool were held to a 3-3 draw against Brentford and will need their defence to improve with the threat of City up top.
Liverpool v Man City: Date and time
Liverpool will host City at Anfield on Sunday, October 3.
The Premier League clash will kick off at 4:30pm.
Liverpool v Man City: TV channel and live stream
The top of the table battle will be broadcast live on Sky Sports Main Event and Sky Sports Premier League with live coverage starting from 4pm.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £9.99.
Liverpool v Man City: Team news
Trent Alexander-Arnold's fitness remains the chief concern for Liverpool after he suffered an injury in the draw against Brentford.
The right-back missed the trip to Portugal in midweek and was left out of Gareth Southgate's England squad for the upcoming World Cup qualifiers.
Liverpool have no other fresh injury concerns with Thiago Alcantara and Harvey Elliott already ruled out with more serious injuries.
Pep Guardiola will be once again without influential midfielder Ilkay Gundogan after he picked up a thigh problem against Southampton.
The German scored during City's 4-1 win over Liverpool at Anfield last campaign but is not expected to be back until after the international break.
Oleksandr Zinchenko also remains a major doubt for Sunday's clash with the Ukrainian missing the club's last three matches.
But more positively, John Stones returned to the squad for the 2-0 defeat to Paris Saint-Germain and could start over Aymeric Laporte.
Liverpool v Man City: Match facts
Liverpool haven't lost consecutive league games against Manchester City since a run of four between 1935 and 1937, going down 4-1 the last time the sides met in February.
Manchester City won this exact fixture 4-1 last season, ending a run of 17 away league games without a win at Liverpool (D5 L12). The Citizens haven't won consecutive league games at Anfield since January 1953.
Liverpool have won just one of their last seven Premier League games against reigning champions (D2 L4), beating Manchester City 3-1 at home in their own title winning campaign of 2019-20.
Liverpool are the only side still unbeaten in the Premier League this season (W4 D2), while the Reds have also netted more goals than any other side this term (15). However, Man City have conceded the fewest goals so far in 2021-22 (1), keeping a clean sheet in each of their last five games.
Liverpool are unbeaten in 16 league games (W12 D4), the longest current run without defeat in the top four tiers of English football. However, the Reds conceded more goals in their 3-3 draw at Brentford last time out than they had in their previous eight league games combined (2).
Manchester City haven't faced a shot on target in three of their six Premier League games so far this season (vs Norwich, Arsenal and Chelsea), the same number of games they didn't face a single attempt on target in 38 league games last season.
Man City boss Pep Guardiola has lost more games against Liverpool's Jürgen Klopp in all competitions than he has against any opposing manager in his career (8). Meanwhile, of sides he's faced at least 10 times in all competitions, Guardiola's lowest win rate is against Liverpool (30.8% - W4 D4 L5).
Liverpool's Mohamed Salah has been directly involved in six goals in his five appearances against Manchester City at Anfield in all competitions, scoring four and assisting two.
Man City's Raheem Sterling has scored in two of his last three Premier League games against Liverpool, having failed to find the net in his first eight against his former side. Sterling could become just the second player to score in consecutive Premier League games at Anfield having previously played for the Reds in the competition, after Nicolas Anelka in 2003 and 2004.
Five of Diogo Jota's 12 Premier League goals for Liverpool have been headers (42%) - it's the highest ratio of headed goals of any non-defender for the Reds in the competition's history (min. 10 goals scored).