The champions are a point behind the Foxes after eight games with both sides having impressed so far this season.
The Red 1-1 with Manchester City before the international break while Leicester beat Wolves.
This Sunday's game will be a big one for both but Jurgen Klopp and Brendan Rodgers have plenty to think about before kick-off.
Liverpool saw Joe Gomez join Virgil van Dijk and Fabinho in the treatment room after the defender suffered a knee injury in training for England.
Gomez could well miss the remainder of the campaign, just as Van Dijk is expected to.
Mohamed Salah, meanwhile, contracted COVID-19 during the break and will have to remain in self-isolation for this match.
Trent Alexander-Arnold is also expected to miss out with a calf problem which forced him to pull out of England duty.
Jordan Henderson and Andrew Robertson both picked up niggles on international duty, but are expected to be fit to play.
Thiago Alcantara could also return to play some part with the summer signing expected back in full training this week after his recent injury and Fabinho is fit again too.
For Leicester, Wesley Fofana is a doubt with a knee injury while fellow defenders Timothy Castagne and Caglar Soyuncu are still out.
Kasper Schmeichel will also need a fitness test after a knock to the head.
Wilfred Ndidi, Ricardo Pereira and Daniel Amartey are long-term injury absentees.
A depleted Liverpool face a tricky test against Leicester this weekend as the Premier League returns.