The two top-flight heavyweights have impressed so far in the 2020/21 campaign, winning two from two and playing some brilliant football.
But only one side can maintain that record and it should be a thrilling clash on Merseyside.
These two have met frequently in recent years and clashes last month in the Community Shield.
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Liverpool v Arsenal: Date and kick-off time
This match will be held at Anfield on Monday, September 28 and will kick-off at 8pm.
The time of the game was altered from its original 8:15pm due to the changes in pub opening hours.
Liverpool beat Arsenal 3-1 at home last season with Mohamed Salah scoring twice.
But the Gunners did get the best of the champions in last month's Community Shield, winning on penalties at Wembley.
Liverpool v Arsenal: TV channel and live stream
The game is being broadcast on Sky Sports Main Event and Sky Sports Premier League from 7:45pm and follows their coverage of Fulham v Aston Villa.
Sky Sports customers can live stream this via the app using their mobile, tablet or computer devices.
If not, you can purchase a Sky Sports Day Pass from NowTV for £8.99.
Liverpool v Arsenal: Team news
Liverpool captain Jordan Henderson will miss the visit of Arsenal as he has not fully recovered from the knock which forced him off at half-time of Sunday's win at Chelsea.
Thiago Alcantara looks set to make his full top-flight debut.
Joel Matip remains out and Joe Gomez is doubtful so Fabinho will likely continue to deputise at centre-back.
Arsenal have doubts over defensive trio Kieran Tierney, Sokratis Papastathopoulos and Cedric Soares while Shkodran Mustafi Pablo Mari and Calum Chambers remain out.
Summer signing William Saliba will be looking for his Premier League debut this weekend while new goalkeeper Runar Alex Runarsson should make the squad.
The likes of Edward Nketiah, Nicolas Pepe and David Luiz will also be looking for starts.
Liverpool v Arsenal: Match stats and facts
Liverpool have won their last four home league games against Arsenal - they've not won more consecutively against the Gunners at Anfield since a run of seven between 1981-1988.
Arsenal's 2-1 victory over Liverpool back in July was their first win over the Reds in 10 Premier League games (D4 L5). The Gunners are looking to win back-to-back league games against them for the first time since September 2012.
Since a 1-0 victory over Leicester in April 2017, Arsenal are winless in their last six Premier League games against the reigning champions (D2 L4). However, Arsenal have won each of their last three against Liverpool with the Reds as reigning champions (2-0 in May 1989, 3-0 in December 1990 and 1-0 in March 1991).
Only three top-flight fixtures - Liverpool v Man Utd (27), Chelsea v Man Utd (20) and Arsenal v Man Utd (18) - have seen more defeats for reigning champions than the 16 between Arsenal and Liverpool, with the Gunners enjoying 10 such victories against the Reds.
Liverpool are unbeaten in their last 60 Premier League home games (W49 D11) since a 1-2 loss against Crystal Palace in April 2017. Only Chelsea (86 between 2004-2008) and Liverpool themselves (63 between 1978-1980) have had longer such runs in English top-flight history.
Arsenal are looking to win their opening three games to a Premier League season for the first time since the 2004-05 campaign, when they won their first five.
Since Jürgen Klopp's first Premier League game in charge of Liverpool, only Manchester City (35 v Watford & 30 v Bournemouth) have scored more goals against a side than his Liverpool team has versus Arsenal (27).
In 24 Premier League appearances against Arsenal combined for Liverpool, Roberto Firmino (8), Mohamed Salah (5) and Sadio Mané (5) have netted 67% of the Reds' goals versus the Gunners since August 2015 (18/27), including 10 of the last 12.
Arsenal's Alexandre Lacazette has scored four goals in his last six Premier League games, netting in both of his appearances so far this season. He last scored in three consecutive league games back in February 2019.
Mikel Arteta is looking to become the first Arsenal manager to win on his first away trip to Liverpool in all competitions since Tom Whittaker in December 1947. Nine Gunners managers since then have failed to win their first such visit, with eight of those losing.
Liverpool and Arsenal will both be looking to keep their 100 percent starts to the new Premier League season going when they face off at Anfield on Monday night.