The Magpies take on Arne Slot's Premier League leaders in the Carabao Cup final on Sunday with this season's first piece of silverware on the line.
Liverpool are aiming to retain the trophy they won a year ago against Chelsea whilst Eddie Howe's men are hoping to go one better after suffering defeat to Manchester United in the 2023 final.
Thousands of Newcastle fans famously gathered at Trafalgar Square ahead of the final two years ago.
But anybody expecting a repeat of those scenes will be left short-changed after the Metropolitan Police announced that the London landmark will be closed off to fans.
Instead, supporters of both clubs have been urged to make other arrangements prior to the final which is scheduled to kick off at 4.30pm.
Read more on football
Arne Slot gets Liverpool consolation as Trent Alexander-Arnold heartbreak confirmed
Boss had three-word reaction after star's Man United and Newcastle meetings
A statement from Met Police on Friday read: "In past years, fans from visiting teams have used Trafalgar Square as a gathering point on Saturdays ahead of a Sunday match. That won't be possible this weekend as the square will be closed to prepare for an upcoming event. Fans are advised to make alternative arrangements and to do so in advance.
"While we know many fans will be planning to have a drink and enjoy themselves, it's in everyone's interest that it doesn't cross the line from celebration into antisocial or disorderly behaviour. Officers will intervene swiftly if it does.
"Dispersal orders will be in place in Westminster and around Wembley giving officers the power to require anyone acting in a disorderly way to leave the area.
"Fans should also be aware that Brent Council (in whose area Wembley is located) will be enforcing a no-street-drinking zone on Olympic Way and the surrounding area. It is in place for all events at Wembley Stadium. More information can be found online.
Most read in EFL Cup
Arne Slot gets Liverpool consolation as Trent Alexander-Arnold heartbreak confirmed
How to watch Carabao Cup final for FREE as Liverpool take on Newcastle at Wembley
Alexander-Arnold out of Carabao Cup final for Liverpool as Newcastle look to end drought
What time is the 2025 Carabao Cup final? Liverpool vs Newcastle kick-off in original slot
"A Public Space Protection Order is also in place in the Westminster area which covers much of the West End including Covent Garden. It gives police officers and council officials the ability to confiscate alcohol if individuals are being disorderly. More information can be found online.
"We will have officers deployed both in central London and around Wembley Stadium throughout the weekend to provide a reassuring presence and to respond to any incidents. Any fans with concerns shouldn't hesitate to speak to them."
A full house is expected at Wembley for Sunday's final as Liverpool look to pick up the first of two possible trophies.
The Reds' Champions League exit in midweek has placed even greater importance on Sunday's clash and if they are to make it back-to back wins in the competition then they will have to do it without the injured Trent Alexander-Arnold.
Slot's side are 15 points ahead of the chasing pack in the Premier League and the Dutchman will view a domestic double as the least his side deserve for their dominance this season.
Meanwhile, Howe can lead Newcastle to history by bringing an end to their long trophy drought.
The Magpies are without a major honour since 1955 and a win on Sunday would put Howe into club folklore.
Unseen footage shows Virgil van Dijk spotted talking to PSG chiefs after Liverpool's Champions League exit