The Citizens will enter the contest off the back of a 5-1 defeat to Arsenal in England's top flight, with the result leaving Pep Guardiola's side in fifth spot in the Premier League table, two points behind fourth-placed Chelsea.
Man City were 8-0 winners over Salford City in the third round of the competition, and they will now be bidding to avoid a shock exit to League One side Orient this weekend.
Here, Sports Mole rounds up Man City's latest injury and suspension news ahead of the contest with the London club, who have beaten Boreham Wood, Oldham Athletic and Derby County in this season's FA Cup.
Ederson
Status: Minor doubt
Type of injury: Unspecified
Possible return date: February 8 (vs. Orient)
Ederson was not involved against Arsenal last time out due to a minor problem, but the experienced goalkeeper is expected to be available for selection against Orient in the FA Cup on Saturday.
Rodri
Status: Out
Type of injury: Knee
Possible return date: Unknown
Man City remain without Rodri due to a serious knee injury, which was initially expected to end his season. However, the Spaniard
Written by
Matt Law
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