The Crystal Palace loanee was not signed in time to face Aston Villa on August 31, and he was also ineligible to tackle his parent club in last weekend's enthralling 2-2 draw.
However, Edouard will now be given the green light to make his maiden appearance for Steve Cooper's side, who are only without Patson Daka and Jakub Stolarczyk due to ankle problems.
Any minutes for Edouard should come from the substitutes' bench, though, as Jamie Vardy is certain to continue up front after bagging his second goal of the campaign at Crystal Palace.
The 37-year-old has also been involved in 12 goals in his last eight Premier League starts against teams at the bottom of the table - nine of his own and three assists - and should join Jordan Ayew and Stephy Mavididi up top.
Also featuring in the final third should be Wilfred Ndidi, who set up two goals in one Premier League game for the first time last weekend, while Harry Winks and Oliver Skipp hold the fort further back.
Caleb Okoli appears to have ousted Jannik Vestergaard from the backline, and the Italian should link arms with James Justin, Wout Faes and Victor Kristiansen ahead of Mads Hermansen.
Leicester City possible starting lineup:
Hermansen; Justin, Okoli, Faes, Kristiansen; Winks, Skipp; Ayew, Ndidi, Mavididi; Vardy