Meanwhile, the Foxes will be desperate to claim all three points after failing to win their last five matches in all competitions.
Match preview
Leicester saw their FA Cup cup dreams ended by an extra-time defeat to Tottenham Hotspur in the semi-final clash earlier this month.
After experiencing a disappointing result against one North London club, Leicester were beaten by another in last Sunday's league meeting with Arsenal.
A Beth Mead brace and an Alessia Russo effort condemned the Foxes to a heavy 5-0 defeat, extending their winless run to five matches in all competitions.
Although they have endured a poor run of form, Leicester can be pleased with the fact they are guaranteed to be in the WSL next season, having established an 11-point gap over basement side Bristol City with just three games left to play.
With safety secured, Leicester's main objective for the weekend will be to claim their first-ever WSL victory over Man United.
Man United have experienced mixed results this term, having reached the FA Cup final but fallen short of expectations in the league.
Last weekend, Maya Le Tissier netted a stoppage-time equaliser to salvage a 2-2 draw in their home meeting with Brighton & Hove Albion.
Unfortunately for Man United, that result all but ended their top-three hopes, with nine points separating them from third-place Arsenal, who have a significant goal-difference advantage.
As a result, the Red Devils can only maintain their current standing in fourth position, which represents a notable drop off from last season's title fight and second-place finish.
However, Man United will still be determined to build momentum over their next two games against Leicester and Liverpool, before they face Tottenham with the chance to win their first major trophy in the FA Cup final on May 12.
Leicester Women Women's Super League form:
W
L
L
L
D
L
Leicester Women form (all competitions):
L
L
L
D
L
L
Manchester United Women Women's Super League form:
L
D
W
L
W
D
Manchester United Women form (all competitions):
D
W
L
W
W
D
Team News
Leicester's interim boss Jennifer Foster has revealed that Shannon O'Brien and Denny Draper will miss out due to injury.
Josie Green could be recalled to the Leicester defence after dropping down to the bench for the defeat to Arsenal.
German forward Lena Petermann will look to add to her five-goal league tally when she leads the line against Man United.
As for the Red Devils, they are still unable to call upon the services of Gabby George, Emma Watson and Jess Simpson.
Marc Skinner has confirmed that Jayde Riviere is training individually and could be in contention to face Liverpool next week.
The Man United boss could be tempted to make a couple of changes, with Hannah Blundell and Lucia Garcia both in contention to start against Leicester.
Leicester Women possible starting lineup:
Kop; Bott, Green, Howard, Cayman; Rose, Tierney, Takarada, Momiki, Rantala; Petermann
Manchester United Women possible starting lineup:
Earps; Mannion, Le Tissier, Turner, Blundell; Naalsund, Zelem; Malard, Toone, Garcia; Parris