Meanwhile, the visitors will be looking to get off the mark as well in what has been a disastrous start to the 2024-25 Turkish Super Lig season.
Match preview
Kayserispor were knocked out of the Turkish Cup in the third round after losing 4-2 against fourth-division side Silivrispor on Wednesday.
Back in the Super Lig, the Anatolian Stars finally registered their first win of the season after nine matches, edging Hatayspor 1-0 at the Mersin Stadyumu last Saturday courtesy of Kartal Yilmaz's 76th-minute goal.
It was Sinan Kaloglu's second game in charge of the team, and the team is already evolving positively after showing some resilience to come from behind twice in the 2-2 draw with Gaziantep the week before.
The Anatolian Stars are still in the relegation zone, currently sitting in 17th with eight points, but they are now just one point from safety as they head into Saturday's clash against the league's whipping boys.
Kayserispor will see this as the perfect opportunity to pick up a first-ever top-flight win against Adana, having lost one and drawn five of the six Super Lig encounters between them.
Across all competitions, the last time that the Anatolian Stars won in this fixture was as far back as 2014 when both teams met in the second division, and they have met nine times since then.
Adana Demirspor scored first for the second straight game and failed to hold on to the lead, losing 4-2 against Sivasspor at the New Adana Stadium last Friday.
Yusuf Barasi and Semih Guler scored in the 13th and 16th minutes to hand the Blue Lightnings what seemed like a comfortable two-goal lead, but Sivasspor pulled one back in the first half and went on to score three goals in the second half to hand Adana their eighth defeat in nine league games.
Serkan Damla was appointed as caretaker manager following the sacking of Michael Valkanis on September 23, but he has since lost all three matches he has taken charge of to date.
The draw with Kasimpasa on matchday three is the sole point Adana has so far this season, and this has left them bottom of the league, eight points away from safety.
The Blue Lightnings are on a six-match losing streak heading into Saturday's clash and a 12-match winless run in the Super Lig dating back to the previous season, streaks they will hope to end at a stadium they have not lost in since 2003.
Kayserispor Turkish Super Lig form:
D
L
L
D
D
W
Adana Demirspor Turkish Super Lig form:
L
L
L
L
L
L
Team News
Kayserispor will remain without 28-year-old centre-back Majid Hosseini, who is sidelined with a foot injury until next month.
Miguel Cardoso and Duckens Nazon started as the front two in the win over Hatayspor, and are both likely to retain their places for Saturday's clash.
Caretaker coach Damla will have a fully fit and available Adana Demirspor squad to select from, just like the last game.
Barasi has scored four of the visitors' nine goals and he will be the man to watch for Adana once again as he leads the line.
Kayserispor possible starting lineup:
Bayazit; Sazdagi, Carole, Janvier, Attamah, Kaldirim; Bourabia, Yilmaz, Gezek; Nazon, Cardoso
Adana Demirspor possible starting lineup:
Karakus; Kurtulan, Guler, Gravillon, Burak; Maestro, Celik; Kol, Aydogan, Kavrazli; Barasi