The Juventus centre-back came off after 84 minutes on Wednesday with an unspecified injury problem, and Louis van Gaal will take no risks while he has options in reserve for the League A Group 4 showdown.
Nathan Ake should therefore come back in to partner Stefan de Vrij, with Virgil van Dijk leaving for his holidays and Jordan Teze not enjoying the finest debut for Oranje in midweek.
Tim Krul has also been forced to withdraw due to injury and has been replaced by Kjell Scherpen, but Jasper Cillessen will likely wrestle the gloves off Mark Flekken, while Denzel Dumfries and Daley Blind are set for recalls in the wide areas.
Teun Koopmeiners can expect to hold his place in midfield, where Frenkie de Jong and Davy Klaassen will both expect to return as Jerdy Schouten makes way.
A trio of well-rested attackers in Memphis Depay, Steven Bergwijn and Steven Berghuis are all ready to return to the XI here, in spite of Wout Weghorst's brilliant header to snatch all three points against Wales.
Cody Gakpo and Noa Lang should therefore make way, with Van Gaal also admitting that the former did not do himself justice from the first whistle in Cardiff.
Netherlands possible starting lineup: Cillessen; Dumfries, De Vrij, Ake, Blind; De Jong, Koopmeiners, Klaassen; Berghuis, Depay, Bergwijn