The Israeli attacker is believed to have suffered a serious knee injury in training, and he represents one of eight injury concerns for the Spurs head coach ahead of the trip to Kenilworth Road.
Several of Tottenham's fitness worries come on the left-hand side of the attack, where Ivan Perisic (ACL) and Ryan Sessegnon (hamstring) are also absent, while Bryan Gil is thought to be back in training from groin surgery but is unlikely to be thrown back into the deep end just yet.
Furthermore, Brennan Johnson has been omitted from the latest Wales squad due to his hamstring injury, which will seemingly render him unavailable here too, so Richarlison is a surefire starter after linking up with Son Heung-min for his side's opener in their dramatic 2-1 win over Liverpool.
Captain Son is in line to start at the tip of the Spurs attack in that case, while Dejan Kulusevski and James Maddison - whose knee injury did not prove serious - complete the visitors' forward line.
Neither Rodrigo Bentancur (knee) nor Giovani Lo Celso (thigh) will be available at Kenilworth Road, but the effective pairing of Yves Bissouma and Pape Sarr was never likely to be broken up.
Both of Spurs' full-backs were at the heart of their win over Liverpool, as two perceived fouls from Diogo Jota on Destiny Udogie saw the Liverpool man sent off, while Pedro Porro's last-gasp cross was turned into the Reds' net by Joel Matip.
Udogie was subjected to sickening racist abuse online after the game, but there is nothing to suggest that the Italian will not join Porro, Cristian Romero, Micky van de Ven and Guglielmo Vicario in the rearguard, as Alfie Whiteman also battles back from an ankle operation.
Tottenham Hotspur possible starting lineup: Vicario; Porro, Romero, Van de Ven, Udogie; Sarr, Bissouma; Kulusevski, Maddison, Richarlison; Son