The injured trio of Pedri, Bryan Gil and Gerard Moreno were all forced to withdraw prior to their 3-0 win over Norway, but La Roja came through that opening triumph unscathed.
Fewer than two minutes after being brought on for his senior international debut at the age of 32, Joselu had a brace to his name against Norway, netting from close range twice just 106 seconds apart.
However, the Espanyol attacker should not trouble captain Alvaro Morata for the number nine spot, while Dani Olmo's spot on the right is also safe following his opener on Saturday night.
Mikel Oyarzabal is threatening Gavi's place on the left, but the Barcelona protege should retain his place for the time being, and De la Fuente is facing perhaps his biggest dilemma in the number 10 role.
Iago Aspas lasted just 58 minutes in his first Spain start since 2019 at the weekend, and Fabian Ruiz - who set up Joselu's header - could force his way into the first XI.
Mikel Merino and Rodri will expect to link arms in the engine room once more, after the latter somehow escaped giving away a penalty for a reckless challenge on Arsenal's Martin Odegaard.
With little reason to change an unsullied backline, all of Alejandro Balde, Dani Carvajal, Nacho Fernandez and Aymeric Laporte should protect Kepa Arrizabalaga once more.
Spain possible starting lineup: Arrizabalaga; Carvajal, Fernandez, Laporte, Balde; Merino, Rodri, Ruiz; Olmo, Morata, Gavi