Dani Carvajal, Ferland Mendy, Gareth Bale and Dani Ceballos will all definitely miss the contest, while Marcelo and Toni Kroos remain doubts amid their recent injury problems.
Carlo Ancelotti's side did not suffer any fresh issues in their goalless draw with Villarreal at the weekend, but there are expected to be changes for the European contest.
Lucas Vazquez could come in for a start at right-back, while Eduardo Camavinga is in line for a position in the middle of the park alongside Casemiro and Luka Modric.
Ancelotti is unlikely to withdraw either Karim Benzema or Vinicius Junior, who have both been in fine form this season, but there is a spot open in the final third of the field.
Rodrygo was withdrawn at the interval against Villarreal, while Bale is injured, so Eden Hazard could be in line for a role in the front three.
Marco Asensio and Federico Valverde are also options for the first XI, but the pair could both be rested with a view to coming back into the side against Espanyol next weekend.
Real Madrid possible starting lineup: Courtois; Vazquez, Militao, Alaba, Nacho; Camavinga, Casemiro, Modric; Hazard, Benzema, Vinicius
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen