Vinicius has had his red card from the 1-0 loss at Valencia last weekend overturned, but he is currently suffering with knee inflammation and is therefore a major doubt for this match.
Los Blancos head coach Carlo Ancelotti will not be taking any chances when it comes to the Brazilian's fitness, so it would not be a surprise to see him left out of the squad.
Benzema, meanwhile, suffered a nasty cut on his foot during Wednesday's 2-1 win over Rayo Vallecano, with the striker needing stitches to close up the wound.
As a result, the Frenchman is also a major doubt for the clash with Sevilla, which could lead to Rodrygo operating through the middle and Marco Asensio being introduced into a wide area.
Mariano Diaz could be another option, but the striker was absent against Rayo due to a muscular problem, and he is set to leave the club on a free transfer this summer.
Ancelotti is expected to again shuffle his pack for this match, with Dani Ceballos and Aurelien Tchouameni potentially both coming into the midfield.
Eder Militao was an unused substitute last time out, meanwhile, so the Brazil international should also return to the starting side for the contest at Estadio Ramon.
Real Madrid possible starting lineup: Courtois; Carvajal, Militao, Rudiger, Alaba; Camavinga, Tchouameni, Ceballos; Valverde, Rodrygo, Asensio