The Bianconeri, though, arrive in Naples with just one point from their two opening matches - and with some attacking absences to cater for.
In-form Italy winger Federico Chiesa has been ruled out of the squad to visit Stadio Maradona as a precautionary measure protect an ongoing hamstring problem, while Paulo Dybala may only return to Italian soil hours before kickoff and is likely only to feature on the bench.
With Chiesa sidelined, Juve coach Max Allegri could be poised to pick Spain striker Alvaro Morata and Azzurri starlet Moise Kean, who returns to his old club after netting twice in Italy's midweek win over Lithuania. Sweden's Dejan Kulusevski is also set to play a part, and could start out wide.
After playing World Cup qualifiers with their respective countries on Thursday night, Dybala and another South American star, Juan Cuadrado, will give Allegri some tough selection calls to make.
Brazilian pair Kaio Jorge and Arthur remain absent for the Bianconeri, while Aaron Ramsey is yet to recover from his latest injury setback and will also sit out the trip south.
As ever, it remains a three-way shootout for two central-defensive places this week, with either Giorgio Chiellini and long-time colleague Leonardo Bonucci likely to partner Matthijs de Ligt at the back in a possible 4-4-2 formation.
Juventus possible starting lineup: Szczesny; Cuadrado, De Ligt, Chiellini, De Sciglio; Kulusevski, Locatelli, Rabiot, Bernardeschi; Morata, Kean